Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

NCT00001885 | Completed

• 2 other identifiers: 99006999-H-0069
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Data gathered from previous research studies suggest that genetics may play a role in the development of PF in patients with rheumatoid arthritis. However, the actual genetic factors involved in the disease process have not been identified. The goal of this study is to identify the genetic markers in patients with pulmonary fibrosis and rheumatoid arthritis.

Conditions

Healthy; Pulmonary Fibrosis; Rheumatoid Arthritis

Keywords

Interstitial Lung Disease; Inherited Disease; Genetic Markers; Alpha 1 Protease Inhibitor; DNA Mutations; Rheumatoid Arthritis; Pulmonary Fibrosis; Normal Volunteer

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals 21 years of age or older with any of the following:
• RA (based on 1987 American College of Rheumatology Revised Criteria for the Classification of RA) with PF (biopsy-proven), or
• RA-only, or
• Biopsy-proven idiopathic PF-only, or
• Healthy research volunteers.

You may not qualify if:

• Individuals with any of the following:
• Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
• Chronic pulmonary disorders other than pulmonary fibrosis.
• Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
• Non-rheumatoid arthritis.
• Viral infections associated with PF (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
• Pregnancy.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Hakala M. Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fibrosis. Chest. 1988 Jan;93(1):114-8. doi: 10.1378/chest.93.1.114.

  PMID: 3335140 BACKGROUND

MeSH Terms

Conditions

Pulmonary Fibrosis; Arthritis, Rheumatoid; Lung Diseases, Interstitial; Genetic Diseases, Inborn; alpha 1-Antitrypsin Deficiency

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Liver Diseases; Digestive System Diseases; Subcutaneous Emphysema; Emphysema

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: March 21, 1999
• Study Completion: December 28, 2007
• Last Updated: July 2, 2017

Record last verified: 2007-12-28

Locations

US (1)