NCT00001544|Completed
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Sponsor study identifier
Secondary identifiers
observational
1,227
1 country
1
Study Start
April 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
March 2004
Date type not reportedThis date has not been verified as actual or estimated.
The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder. The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several molecular genetic techniques in order to identify the areas of chromosomes containing genes responsible for the development of these disorders. Patients will be selected to participate in this study based on an early age of onset of their condition as well as the severity of the illness and the frequency of the illness among family members. Researchers will collect DNA samples from patients as well as affected and unaffected family members of each patient. The DNA samples collected will be analyzed for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2004
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1996
Date type not reportedThis date has not been verified as actual or estimated.
November 3, 1999
Actual (reported)November 4, 1999
Actual (reported)March 2004
Date type not reportedThis date has not been verified as actual or estimated.
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National Institute of Mental Health (NIMH)
Bethesda, Maryland, 20892, United States
Willems PJ. Dynamic mutations hit double figures. Nat Genet. 1994 Nov;8(3):213-5. doi: 10.1038/ng1194-213. No abstract available.
Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T, et al. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet. 1994 Jan;6(1):9-13. doi: 10.1038/ng0194-9.
Philibert RA, Hawkins GA, Damschroder-Williams P, Stubblefield BK, Martin BM, Ginns EI. Direct sequencing of trinucleotide repeats from cosmid genomic DNA template. Anal Biochem. 1995 Mar 1;225(2):372-4. doi: 10.1006/abio.1995.1174. No abstract available.
First Submitted
November 3, 1999
First Posted
November 4, 1999
Study Start
April 1996
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
March 2004
Date type not reportedThis date has not been verified as actual or estimated.
Self-Management Therapy for Youth With Schizophrenia
Last Updated
March 4, 2008
Record last verified: 2004-03
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Source: ClinicalTrials.gov.
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