Genetic Aspects of Neurologic and Psychiatric Disorders

NCT00001544 | Completed

• 2 other identifiers: 96006096-M-0060
• Study Type: observational
• Target: 1,227
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder. The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several molecular genetic techniques in order to identify the areas of chromosomes containing genes responsible for the development of these disorders. Patients will be selected to participate in this study based on an early age of onset of their condition as well as the severity of the illness and the frequency of the illness among family members. Researchers will collect DNA samples from patients as well as affected and unaffected family members of each patient. The DNA samples collected will be analyzed for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms.

Conditions

Attention Deficit Disorder With Hyperactivity; Bipolar Disorder; Mental Disorder Diagnosed in Childhood; Mental Retardation; Schizophrenia

Keywords

DNA Probes; Trinucleotide Repeats; Family Studies; Lymphoblast Cell Lines; Genotyping; Bipolar Affective Disorders; Schizophrenia; Mental Retardation; Neuropsychiatric Disorders

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals with selected psychiatric and neurologic disorders, including childhood onset schizophrenia, atypical psychosis, mental retardation, bipolar affective disorder, and ADHD.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (1)

National Institute of Mental Health (NIMH)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Willems PJ. Dynamic mutations hit double figures. Nat Genet. 1994 Nov;8(3):213-5. doi: 10.1038/ng1194-213. No abstract available.

  PMID: 7874160 BACKGROUND

• Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T, et al. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet. 1994 Jan;6(1):9-13. doi: 10.1038/ng0194-9.

  PMID: 8136840 BACKGROUND

• Philibert RA, Hawkins GA, Damschroder-Williams P, Stubblefield BK, Martin BM, Ginns EI. Direct sequencing of trinucleotide repeats from cosmid genomic DNA template. Anal Biochem. 1995 Mar 1;225(2):372-4. doi: 10.1006/abio.1995.1174. No abstract available.

  PMID: 7762809 BACKGROUND

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Intellectual Disability; Schizophrenia

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders; Bipolar and Related Disorders; Mood Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Schizophrenia Spectrum and Other Psychotic Disorders

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: April 1, 1996
• Study Completion: March 1, 2004
• Last Updated: March 4, 2008

Record last verified: 2004-03

Locations

US (1)