NCT00001545|CompletedPhase 2
Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders
Evaluation of rTMS in the Treatment of Mood Disorders
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Evaluation of rTMS in the Treatment of Mood Disorders
Sponsor study identifier
Secondary identifiers
interventional
91
1 country
1
Study Start
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
This study is designed to evaluate repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for depression. In rTMS, a rapidly changing magnetic field passes through your scalp and skull and generates a small electrical pulses in your brain. rTMS at lower intensities has helped some people with depression but we do not know what the results will be in your case using higher intensities, or whether you will be randomized to 3 weeks of high frequency (20 cycles er second), low frequency (1 cycle per second), or inactive (sham)rTMS. You will be assigned to receive one of these types of rTMS over the left front art of your brain five times per week for the three weeks. Each rTMS treatment session should take between 20-30 minutes of actual stimulation, but weekly ratings, memory testing, and blood sampling may require several hours per week. We will also ask you to have brain imaging procedures to see if these will predict response to high vs. low frequency rTMS. If you are randomized to the 3 weeks of sham rTMS, you will have the opportunity to receive one of the active stimulation frequencies for an additional 3 weeks. Responders to any phase will be offered an additional month of rTMS prior to study termination and recommendations of alternative treatments.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
November 3, 1999
Actual (reported)November 4, 1999
Actual (reported)July 2006
Date type not reportedThis date has not been verified as actual or estimated.
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National Institute of Mental Health (NIMH)
Bethesda, Maryland, 20892, United States
Speer AM, Kimbrell TA, Wassermann EM, D Repella J, Willis MW, Herscovitch P, Post RM. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry. 2000 Dec 15;48(12):1133-41. doi: 10.1016/s0006-3223(00)01065-9.
First Submitted
November 3, 1999
First Posted
November 4, 1999
Study Start
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
rTMS for Treatment of Depressed Phase of Bipolar Disorder Type II
Contact the study team to confirm eligibility.
Last Updated
July 13, 2006
Record last verified: 2006-07
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Source: ClinicalTrials.gov.
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