PET Scan to Study Brain Control of Human Movement

NCT00001324 | Completed

• 2 other identifiers: 92011992-N-0119
• Study Type: observational
• Target: 510
• Locations: 1 country
• Sites: 1

Brief Summary

Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases, blood flow to and from the area of activity also increases. This is known as regional cerebral blood flow (rCBF). Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. In this study researchers plan to investigate the changes in regional cerebral blood flow (rCBF) as patients participate in different activities. The activities are designed to stimulate the areas of the brain responsible for voluntary motor activity and sensation. By comparing the results of PET scans performed in different conditions, researchers can locate regions of the brain responsible for specific tasks. This study should provide new information about voluntary movements in humans and the preparation involved in controlling them.

Conditions

Ataxia; Cerebrovascular Accident; Healthy; Movement Disorder; Tremor

Keywords

Ataxia; Brain; Motor Learning; Parkinson's Disease; Physiology; Positron Emission Tomography; Stroke; Tremor; Voluntary and Involuntary Movement Physiology; Movement Disorders; Normal Volunteer

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Patients with movement disorder and normal volunteers.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Deiber MP, Ibanez V, Honda M, Sadato N, Raman R, Hallett M. Cerebral processes related to visuomotor imagery and generation of simple finger movements studied with positron emission tomography. Neuroimage. 1998 Feb;7(2):73-85. doi: 10.1006/nimg.1997.0314.

  PMID: 9571132 BACKGROUND

• Catalan MJ, Honda M, Weeks RA, Cohen LG, Hallett M. The functional neuroanatomy of simple and complex sequential finger movements: a PET study. Brain. 1998 Feb;121 ( Pt 2):253-64. doi: 10.1093/brain/121.2.253.

  PMID: 9549504 BACKGROUND

• Deiber MP, Wise SP, Honda M, Catalan MJ, Grafman J, Hallett M. Frontal and parietal networks for conditional motor learning: a positron emission tomography study. J Neurophysiol. 1997 Aug;78(2):977-91. doi: 10.1152/jn.1997.78.2.977.

  PMID: 9307128 BACKGROUND

MeSH Terms

Conditions

Ataxia; Stroke; Movement Disorders; Tremor; Parkinson Disease

Condition Hierarchy (Ancestors)

Dyskinesias; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: December 10, 2002
• Study Start: March 1, 1992
• Study Completion: July 1, 2001
• Last Updated: March 16, 2021

Record last verified: 2000-03

Locations

US (1)