Study of Brain Control of Movement

NCT00017979 | Completed

• 2 other identifiers: 01020001-N-0200
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease. Normal healthy volunteers between the ages of 18 and 65 years may be eligible to participate. In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's scalp or skin. Brief electrical currents are passed through the coil, creating magnetic pulses that stimulate the brain. During the stimulation, participants will be asked to tense certain muscles slightly or perform other simple actions. The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle. In most cases, the study will last less than 3 hours.

Conditions

Movement Disorder; Healthy

Keywords

Transcranial Magnetic Stimulation; Motor Cortex; Motor Imagery; Reaction Time; Cerebral Inhibition; Healthy Volunteer; Normal Control

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Volunteers who are greater than or equal to 18 years old. Subjects must not have any medico-surgical illness. Subjects must not have neurological illness. Subjects must not have psychiatric illness. Subjects must not be taking any medication with potential influence on nervous system function. Subjects must not have a pacemaker. Subjects must not have an implanted medical pump. Subjects must not have a metal plate or a metal object in the skull or eye. Subjects must not have a history of seizure disorder.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Triggs WJ, Cros D, Macdonell RA, Chiappa KH, Fang J, Day BJ. Cortical and spinal motor excitability during the transcranial magnetic stimulation silent period in humans. Brain Res. 1993 Nov 19;628(1-2):39-48. doi: 10.1016/0006-8993(93)90935-g.

  PMID: 8313168 BACKGROUND

• Fuhr P, Agostino R, Hallett M. Spinal motor neuron excitability during the silent period after cortical stimulation. Electroencephalogr Clin Neurophysiol. 1991 Aug;81(4):257-62. doi: 10.1016/0168-5597(91)90011-l.

  PMID: 1714819 BACKGROUND

• Colebatch JG, Rothwell JC, Day BL, Thompson PD, Marsden CD. Cortical outflow to proximal arm muscles in man. Brain. 1990 Dec;113 ( Pt 6):1843-56. doi: 10.1093/brain/113.6.1843.

  PMID: 2276047 BACKGROUND

MeSH Terms

Conditions

Movement Disorders

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 23, 2001
• First Posted: June 25, 2001
• Study Start: June 1, 2001
• Study Completion: June 1, 2002
• Last Updated: March 4, 2008

Record last verified: 2002-06

Locations

US (1)