Study of Norepinephrine Levels and Sympathetic Nervous System Activity

NCT00001329 | Completed

• 2 other identifiers: 92025992-N-0259
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the sympathetic nervous system. The sympathetic nervous system is involved with regulating blood pressure and pulse rate. Researchers believe the level norepinephrine in the blood can be used to measure activity of the sympathetic nervous system. This study is designed to answer important questions about rates of release of norepinephrine into the blood stream, removal of released norepinephrine, and the sympathetic nervous system response to stress. Researchers will attempt to measure levels of norepinephrine and activity of the sympathetic nervous system in patients with high blood pressure, normal patients with family histories of high blood pressure, patients taking drugs that can effect levels of norepinephrine, and patients with diseases or conditions directly affecting the sympathetic nervous system.

Conditions

Autonomic Nervous System Disease; Healthy; Hypertension

Keywords

Yohimbine; Catecholamines; Sympathoadrenal Response; Sympathetic Nervous System; Stress; Hypertension; Autonomic Failure

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Must be greater than or equal to 18 years of age. Must not be pregnant or lactating.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Goldstein DS, Horwitz D, Keiser HR, Polinsky RJ, Kopin IJ. Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension. J Clin Invest. 1983 Nov;72(5):1748-58. doi: 10.1172/JCI111134.

  PMID: 6630523 BACKGROUND

• Rea RF, Eckberg DL, Fritsch JM, Goldstein DS. Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans. Am J Physiol. 1990 Apr;258(4 Pt 2):R982-6. doi: 10.1152/ajpregu.1990.258.4.R982.

  PMID: 2331039 BACKGROUND

• Goldstein DS, Eisenhofer G, Stull R, Folio CJ, Keiser HR, Kopin IJ. Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Invest. 1988 Jan;81(1):213-20. doi: 10.1172/JCI113298.

  PMID: 3335637 BACKGROUND

MeSH Terms

Conditions

Hypertension; Pure Autonomic Failure

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 3, 1999
• First Posted: November 4, 1999
• Study Start: September 1, 1992
• Study Completion: September 1, 2002
• Last Updated: March 4, 2008

Record last verified: 2002-09

Locations

US (1)