NCT00017966

Brief Summary

This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease. Normal healthy volunteers 18 years of age and older may be eligible to participate. In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's scalp or skin. Brief electrical currents are passed through the coil, creating magnetic pulses that stimulate the brain. During the stimulation, participants will be asked to tense certain muscles slightly or perform other simple actions. The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle. In most cases, the study will last less than 3 hours.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2001

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2001

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

June 23, 2001

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 25, 2001

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2002

Completed
Last Updated

March 4, 2008

Status Verified

June 1, 2002

First QC Date

June 23, 2001

Last Update Submit

March 3, 2008

Conditions

Movement DisorderHealthy

Keywords

Transcranial Magnetic StimulationMotor CortexCerebral InhibitionCorpus CallosumEvoked PotentialHealthy VolunteerNormal Control

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Normal adult volunteers 18 or more years old. Subjects must not have medico-surgical illness. Subjects must not have neurological illness. Subjects must not have psychiatric illness. Subjects must not be taking any medication with potential influence on nervous system function. Subjects must not have a pacemaker. Subject must not have an implanted medical pump. Subjects must not have a metal plate or a metal object in the skull or eye. Subjects must not have a history of seizure disorder.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Blakemore C, Carpenter RH, Georgeson MA. Lateral inhibition between orientation detectors in the human visual system. Nature. 1970 Oct 3;228(5266):37-9. doi: 10.1038/228037a0. No abstract available.

    PMID: 5456209BACKGROUND

  • Prince DA, Wilder BJ. Control mechanisms in cortical epileptogenic foci. "Surround" inhibition. Arch Neurol. 1967 Feb;16(2):194-202. doi: 10.1001/archneur.1967.00470200082007. No abstract available.

    PMID: 6018049BACKGROUND

  • Krnjevic K. Role of GABA in cerebral cortex. Can J Physiol Pharmacol. 1997 May;75(5):439-51. No abstract available.

    PMID: 9250378BACKGROUND

MeSH Terms

Conditions

Movement Disorders

Condition Hierarchy (Ancestors)

Central Nervous System DiseasesNervous System Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

June 23, 2001

First Posted

June 25, 2001

Study Start

June 1, 2001

Study Completion

June 1, 2002

Last Updated

March 4, 2008

Record last verified: 2002-06

Locations

US(1)