NCT06304415|Active Not Recruiting
Elevated Lipoprotein(a) in Hospital Staff
LPACO
Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff
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LPACO
Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff
Sponsor study identifier
observational
2,800
1 country
1
Study Start
April 1, 2024
Actual (reported)Primary Completion
December 1, 2035
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 5, 2024
Actual (reported)March 12, 2024
Actual (reported)April 1, 2024
Actual (reported)December 1, 2035
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Distribution and prevalence of elevated Lipoprotein(a)
Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities.
3 years
Correlation of lipoprotein(a) with cardiovascular outcomes
10 years
Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events
10 years
Consenting hospital staff are recruited to this study. Blood test and questionnaires are taken at baseline. Prospective follow-up of cardiovascular events are undertaken.
Working general population
Clinical Trials & Research Unit
Singapore, Singapore, 529889, Singapore
Loh WJ, Watts GF. Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle? Curr Opin Endocrinol Diabetes Obes. 2023 Apr 1;30(2):94-102. doi: 10.1097/MED.0000000000000789. Epub 2022 Dec 5.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK. Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population. Atherosclerosis. 2022 May;349:160-165. doi: 10.1016/j.atherosclerosis.2021.11.018. Epub 2021 Nov 26.
Blood are collected to measure lipoprotein(a) concentrations, genetic variants and biomarkers.
Loh Wann Jia
Singhealth Foundation
First Submitted
March 5, 2024
First Posted
March 12, 2024
Study Start
April 1, 2024
Actual (reported)Primary Completion
December 1, 2035
EstimatedContact the study team to confirm eligibility.
Loh WJ, Chan DC, Mata P, Watts GF. Familial Hypercholesterolemia and Elevated Lipoprotein(a): Cascade Testing and Other Implications for Contextual Models of Care. Front Genet. 2022 Apr 27;13:905941. doi: 10.3389/fgene.2022.905941. eCollection 2022.
Nestel P, Loh WJ, Ward NC, Watts GF. New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease. J Clin Endocrinol Metab. 2022 Nov 23;107(11):e4281-e4294. doi: 10.1210/clinem/dgac541.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgozoglu LS, Catapano AL. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J. 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361.
Loh WJ, Tun MH, Shak B, Phua SK, Lim G, Yap C, Khoo J, Puar T, Heng CK, Foo R, Watts GF, Dalan R, Aw TC. Lipoprotein(a), apolipoprotein B and other lipid biomarkers in Asian healthcare workers. Lipids Health Dis. 2026 Mar 6;25(1):88. doi: 10.1186/s12944-026-02912-7.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
March 18, 2026
Record last verified: 2025-08
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