TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trial
interventional
N/A
1 country
17
Demonstrate that an antibiotic therapy (ATB) of 3 weeks after drainage of pyogenic liver abscess is non-inferior in terms of treatment failure at week 12 after drainage, compared to a 6 weeks ATB.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
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June 19, 2025
Actual (reported)Proportion of patients with a treatment failure between the end of treatment and week 12 after the drainage of the abscess(es).
1. Time to death of any cause
2. Proportion of patients with digestive colonization of MDRB at inclusion and at week 12 after drainage, assessed by rectal swabs.
3. Proportion of participants with treatment failure at the end of the ATB assigned by randomization.
4. Proportion of participants with complete regression of liver abscess(es) images at week 3, week 6, and week 12 after drainage.
5. Time to hospital discharge
Hospital Foch
Suresnes, 92150, France
Centre Hospitalier Universitaire De Dijon
Dijon, 21000, France
Centre Hospitalier Regional Universitaire De Tours
Tours Cedex 9, 37044, France
Geoffrey ROSSI
First Submitted
June 19, 2025
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Centre Hospitalier Sud Francilien
Corbeil Essonnes Cedex, 91106, France
Centre Hospitalier Universitaire Grenoble Alpes
Grenoble Cedex 9, 38043, France
Centre Hospitalier Universitaire De Rennes
Rennes, 35000, France
Assistance Publique Hopitaux De Paris
Paris, 75014, France
Centre Hospitalier Universitaire De Montpellier
Montpellier Cedex 5, 34295, France
CHU Besancon
Besancon Cedex, 25030, France
Hospices Civils De Lyon
Lyon Cedex 04, 69317, France
Assistance Publique Hopitaux De Paris
Creteil Cedex, 94010, France
Assistance Publique Hopitaux De Paris
Creteil Cedex, 94010, France
Centre Hospitalier Universitaire D'Angers
Angers, 49100, France
Assistance Publique Hopitaux De Paris
Paris, 75012, France
Centre Hospitalier Universitaire De Rennes
Rennes, 35000, France
Hospices Civils De Lyon
Lyon Cedex 04, 69317, France
Assistance Publique Hopitaux De Paris
Clichy, 92110, France