NCT07303829

Brief Summary

Assess the efficacy and safety of laparoscopic management of liver abscess in achieving complete drainage and clinical recovery compared to conventional open or percutaneous methods, and to:

  1. 1.To evaluate postoperative complications and recurrence rates.
  2. 2.To compare hospital stay, recovery time, and overall morbidity.
  3. 3.To determine patient outcomes and cost-effectiveness of laparoscopic intervention.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
8mo left

Started Jan 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress35%
Jan 2026Jan 2027

First Submitted

Initial submission to the registry

November 20, 2025

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 26, 2025

Completed
6 days until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

December 26, 2025

Status Verified

December 1, 2025

Enrollment Period

11 months

First QC Date

November 20, 2025

Last Update Submit

December 22, 2025

Conditions

Liver Abscess, Pyogenic

Outcome Measures

Primary Outcomes (2)

  • Major complication rate

    Procedure-related complications (Clavien-Dindo ≥ III) within 30 days.

    30 days

  • Abscess recurrence

    Recurrence at the same or new site

    6 months.

Secondary Outcomes (1)

  • Technical success

    30days

Study Arms (1)

Laproscopic managment

EXPERIMENTAL
Device: Laproscopic

Interventions

LaproscopicDEVICE

Laparoscopic management uses minimally invasive trocar access with camera-guided drainage and debridement, allowing precise abscess evacuation, reduced tissue trauma, faster recovery, and lower postoperative pain compared with open surgery or percutaneous drainage used in other studies.

Laproscopic managment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults ≥18 years.
  • Radiologically confirmed liver abscess (US/CT/MRI).
  • Abscess requiring drainage ≥5 cm,
  • Failed or contraindicated percutaneous drainage.
  • Recurrence after percutaneous drainage.

You may not qualify if:

  • Adults ≥18 years.
  • Radiologically confirmed liver abscess (US/CT/MRI).
  • Abscess requiring drainage ≥5 cm,
  • Failed or contraindicated percutaneous drainage.
  • Recurrence after percutaneous drainage.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (8)

  • Ndong A, Tendeng JN, Diallo AC, Dieye A, Diao ML, Diallo S, Diop S, Diallo MK, Diedhiou M, Fall ML, Ma Nyemb PM, Konate I. Efficacy of laparoscopic surgery in the treatment of hepatic abscess: A systematic review and meta-analysis. Ann Med Surg (Lond). 2022 Jan 31;75:103308. doi: 10.1016/j.amsu.2022.103308. eCollection 2022 Mar.

    PMID: 35198179RESULT

  • Teresi JA, Yu X, Stewart AL, Hays RD. Guidelines for Designing and Evaluating Feasibility Pilot Studies. Med Care. 2022 Jan 1;60(1):95-103. doi: 10.1097/MLR.0000000000001664.

    PMID: 34812790RESULT

  • Whitehead AL, Julious SA, Cooper CL, Campbell MJ. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Stat Methods Med Res. 2016 Jun;25(3):1057-73. doi: 10.1177/0962280215588241. Epub 2015 Jun 19.

    PMID: 26092476RESULT

  • Julious SA. Sample size of 12 per group rule of thumb for a pilot study. Pharm Stat. 2005;4(4):287-291.

    RESULT

  • International Journal of Surgery. Laparoscopic Drainage of Pyogenic Liver Abscess: A Feasible Alternative. https://www.ijsurgery.com/index.php/isj/article/view/9473

    RESULT

  • Bansal V, et al. Systematic Review of Laparoscopic Drainage of Liver Abscess. Cureus. 2022;14(2):e22045. https://pmc.ncbi.nlm.nih.gov/articles/PMC8850317

    RESULT

  • Saravanan R, et al. Comparative Study of Laparoscopic Versus Open Surgical Drainage in Pyogenic Liver Abscess. SAR J Surg. 2024. https://sarpublication.com/media/articles/SARJS_62_10-14.pdf

    RESULT

  • Medscape. Liver Abscess Treatment & Management. https://emedicine.medscape.com/article/188802-treatment

    RESULT

MeSH Terms

Conditions

Liver Abscess, Pyogenic

Condition Hierarchy (Ancestors)

Liver AbscessAbdominal AbscessAbscessSuppurationInfectionsLiver DiseasesDigestive System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor

Study Record Dates

First Submitted

November 20, 2025

First Posted

December 26, 2025

Study Start

January 1, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

January 1, 2027

Last Updated

December 26, 2025

Record last verified: 2025-12