An Observational Study of Risk Factors and Long-term Prognosis of Patients With Liver Abscess in the "Real-world"

NCT05213949 | Unknown

• 1 other identifier: NFEC-2021-355
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Pyogenic liver abscess is one of the most common visceral abscesses, its incidence is increasing worldwide. According to the previous literature, the mortality rate of pyogenic liver abscess is as high as 31% and become a serious social health problem. However, the data of prospective observational real-world studies are scarce and no relevant research of the liver histological change has been reported, so the long-term prognosis and the risk factors for pyogenic liver abscess are still unknown. Patients will be followed up prospectively for a period of 2 years and observed clinical prognosis (all-cause mortality, the recurrence rate, and the rehospitalization rate). The investigators will investigate the predictive value of clinical risk factors for clinical prognosis and establish clinical prediction models to predict the long-term prognosis of pyogenic liver abscesses.

Conditions

Liver Abscess, Pyogenic; Liver Abscess; Abscess; Infections

Keywords

Pyogenic Liver abscess; Liver histological change

Outcome Measures

Primary Outcomes (2)

• Proportion and causes of deaths within 2 years of discharge from hospital

  Define the proportion and causes of deaths within 2 years of discharge from hospital for patients admitted to the Department for pyogenic liver abscesses.

  2 years

• Proportion and causes of re-hospitalization within 2 years of discharge from hospital

  Define the proportion and causes of re-hospitalization within 2 years of discharge from hospital for patients admitted to the Department for pyogenic liver abscesses.

  2 years

Secondary Outcomes (2)

• The recurrence rate of pyogenic liver abscess

  2 years

• The number of participants with Histological Change in the Liver

  2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients older than 18 years of age admitted for pyogenic liver abscesses

You may qualify if:

• Patients older than 18 years of age;
• Irrespective of gender;
• Symptomatic patients of liver abscess confirmed with radiology imaging, either by ultrasonography or computed tomography scan.

You may not qualify if:

• Patients \<18 years old;
• Pregnancy at presentation.

Sponsors & Collaborators

• Nanfang Hospital, Southern Medical University: lead

Study Sites (1)

NanFang Hospital of Southern Medical University

Guangzhou, Guangdong, 5100515, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Take 10ml blood sample for each patient

MeSH Terms

Conditions

Liver Abscess, Pyogenic; Liver Abscess; Abscess; Infections

Condition Hierarchy (Ancestors)

Abdominal Abscess; Suppuration; Liver Diseases; Digestive System Diseases; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Xuyen Xu, MD

CONTACT

020-62786539; xuxuwen95@126.com

Muye Xia, MD

CONTACT

+86 17665730806; xiamuye@foxmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 30, 2021
• First Posted: January 28, 2022
• Study Start: January 1, 2022
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: August 8, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)