Pyogenic Liver Abcess in Guadeloupe

NCT07579104 | Completed

• 1 other identifier: PAP_RIPH3_2020/19
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Liver abscesses are infections of the liver parenchyma, most often bacterial, occurring via the biliary tract, bloodstream, or by direct spread. Although rare, they are serious, with a mortality rate of around 15%. In Western countries, they are mainly polymicrobial or associated with Escherichia coli, streptococci, and Klebsiella pneumoniae. While overall incidence is low, it appears higher in Guadeloupe. There is a growing increase in cases caused by hypervirulent \*Klebsiella pneumoniae\* (hvKp), which can infect healthy individuals and spread to distant sites such as the eye, lungs, and central nervous system. Its virulence is linked to specific genetic factors. The emergence of multidrug-resistant hypervirulent strains represents a major concern. In Guadeloupe, about ten cases per year are reported, with no clearly identified risk factors.

Conditions

Liver Abscess, Pyogenic

Keywords

Klebsiella pneumoniae; hypervirulence; liver abscess; pyogenic; Guadeloupe

Outcome Measures

Primary Outcomes (1)

• Microbial etiologies associated to pyogenic LA in Guadeloupe

  Identification of bacteria responsible for pyogenic liver abscesses through culture (blood and/or pus), with analysis of their antibiotic susceptibility profile.

  Baseline

Secondary Outcomes (10)

• Clinical presentation of pyogenic LA

  Baseline

• Radiological characteristics of pyogenic liver abscess

  At diagnosis (baseline)

• Radiological features of pyogenic LA

  Baseline

• Risk factors associated with Klebsiella pneumoniae pyogenic liver abscess

  Baseline

• Virulence genes, antimicrobial resistance genes, and molecular typing of Klebsiella pneumoniae isolates

  Baseline

Study Arms (1)

Pyogenic liver abscess cohort

All patients diagnosed with pyogenic liver abscess managed at the participating center during the study period.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Prospective cohort of patients with liver abscesses in Guadeloupe

You may qualify if:

• Patients of 18 years old and older
• Radiological diagnosis of hepatic abscess
• Patients (a close relative if the patient is out of state to give his agreement )who have agreed to participate to the study

You may not qualify if:

• Patients under 18 years old
• Patient (a close relative if the patient is out of state to give his agreement ) who refuse to participate to the study

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead

Study Sites (1)

Chu de La Guadeloupe

Les Abymes, 97159, Guadeloupe

Location

MeSH Terms

Conditions

Liver Abscess, Pyogenic; Liver Abscess

Condition Hierarchy (Ancestors)

Abdominal Abscess; Abscess; Suppuration; Infections; Liver Diseases; Digestive System Diseases

Study Officials

• Sébastien Breurec, MD PhD

  CHU de la Guadeloupe

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: May 11, 2026
• Study Start: March 22, 2021
• Primary Completion: February 15, 2024
• Study Completion: February 15, 2024
• Last Updated: May 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

GU (1)