NCT07579104

Completed

Pyogenic Liver Abcess in Guadeloupe

Centre Hospitalier Universitaire de la Guadeloupe Source

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Other study identifiers

Sponsor study identifier

PAP_RIPH3_2020/19

Study Type

observational

Actual enrollment (reported)

58

Locations

1 country

Sites

1

Timeline

Study Start

March 22, 2021

Actual (reported)

Primary Completion

February 15, 2024

Actual (reported)

Study Completion

February 15, 2024

Actual (reported)

Brief Summary

Liver abscesses are infections of the liver parenchyma, most often bacterial, occurring via the biliary tract, bloodstream, or by direct spread. Although rare, they are serious, with a mortality rate of around 15%. In Western countries, they are mainly polymicrobial or associated with Escherichia coli, streptococci, and Klebsiella pneumoniae. While overall incidence is low, it appears higher in Guadeloupe. There is a growing increase in cases caused by hypervirulent \*Klebsiella pneumoniae\* (hvKp), which can infect healthy individuals and spread to distant sites such as the eye, lungs, and central nervous system. Its virulence is linked to specific genetic factors. The emergence of multidrug-resistant hypervirulent strains represents a major concern. In Guadeloupe, about ten cases per year are reported, with no clearly identified risk factors.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 58 participants
Study completion date: February 15, 2024
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
March 22, 2021
Actual (reported)
Primary Completion
February 15, 2024
Actual (reported)
Study Completion
February 15, 2024
Actual (reported)
First Submitted
February 10, 2025
Actual (reported)
First Posted
May 11, 2026
Actual (reported)

Last Updated: May 11, 2026
Status Verified: May 2026
Last Update Submitted: May 6, 2026

Conditions

Liver Abscess, Pyogenic

Keywords

Klebsiella pneumoniaehypervirulenceliver abscesspyogenicGuadeloupe

Outcome Measures

Primary Outcomes (1)

Microbial etiologies associated to pyogenic LA in Guadeloupe
Identification of bacteria responsible for pyogenic liver abscesses through culture (blood and/or pus), with analysis of their antibiotic susceptibility profile.
Baseline

Secondary Outcomes (10)

Clinical presentation of pyogenic LA
Baseline
Radiological characteristics of pyogenic liver abscess
At diagnosis (baseline)
Radiological features of pyogenic LA
Baseline
Risk factors associated with Klebsiella pneumoniae pyogenic liver abscess
Baseline
Virulence genes, antimicrobial resistance genes, and molecular typing of Klebsiella pneumoniae isolates
Baseline
+5 more secondary outcomes

Study Arms (1)

Pyogenic liver abscess cohort

All patients diagnosed with pyogenic liver abscess managed at the participating center during the study period.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Prospective cohort of patients with liver abscesses in Guadeloupe

You may qualify if:

Patients of 18 years old and older

Sponsors & Collaborators

Centre Hospitalier Universitaire de la Guadeloupe
Otherlead

Study Sites (1)

Chu de La Guadeloupe

Les Abymes, 97159, Guadeloupe

MeSH Terms

Conditions

Liver Abscess, PyogenicLiver Abscess

Condition Hierarchy (Ancestors)

Abdominal AbscessAbscessSuppurationInfectionsLiver DiseasesDigestive System Diseases

Study Officials

Sébastien Breurec, MD PhD
CHU de la Guadeloupe
STUDY DIRECTOR

Enrollment

58 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: OTHER
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

February 10, 2025

First Posted

May 11, 2026

Study Start

March 22, 2021

Actual (reported)

Radiological diagnosis of hepatic abscess

Patients (a close relative if the patient is out of state to give his agreement )who have agreed to participate to the study

You may not qualify if:

Patients under 18 years old
Patient (a close relative if the patient is out of state to give his agreement ) who refuse to participate to the study

Contact the study team to confirm eligibility.

Primary Completion

February 15, 2024

Actual (reported)

Study Completion

February 15, 2024

Actual (reported)

Last Updated

May 11, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT07579104
Data provider: ClinicalTrials.gov
Source updated: 2026-05-11
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:28:53 UTC

Locations

GP(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (10)

Study Arms (1)

Pyogenic liver abscess cohort

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations