Biologically Oriented Alveolar Ridge Preservation (BARP) With and Without Advanced Platelet-Rich Fibrin Plus (A-PRF+)

NCT07869082 | Completed

• 1 other identifier: MDP.25.09.23
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Twenty patients were selected from the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking for extraction of non-restorable maxillary premolar teeth prior to delayed implant placement. Patients will be divided into 2 groups:

• Group A: 10 implants were inserted after four months from extraction after socket preservation by putting two collagen sponge layers and in between deproteinized bovine bone.
• Group B: 10 implants were inserted after four months after socket preservation by putting two collagen sponge and in between deproteinized bovine bone with addition of advanced PRF plus layer.
• Closure of the flap was obtained without tension. Implants of all groups were immediately loaded .Some Clinical and Radiographic parameters and Histological and Volumetric evaluation were made at different time intervals along this study.

Conditions

Alveolar Bone Loss

Outcome Measures

Primary Outcomes (1)

• Implant stability

  Implant stability measured using Resonance Frequency Analysis (RFA) with the Osstell Mentor device and SmartPeg. Measurements were recorded in four directions (every 90 degrees) and averaged per implant to provide an ISQ score (scale: 1 to 100, where higher scores indicate greater stability).

  6 months

Study Arms (2)

Deproteinized bovine

EXPERIMENTAL

Deproteinized bovine bone with collagen sponge was used for socket preservation for 10 cases and implant placement was performed after four months.

Procedure: Socket preservation by deproteinized bovine bone graft

Deproteinized bovine bone with advanced PRF

EXPERIMENTAL

Deproteinized bovine bone with advanced PRF+ and collagen sponge was used for socket preservation for 10 cases then implant placement was performed after four months.

Procedure: socket preservation by deproteinized bovine bone graft mixed with advanced PRF+

Interventions

Socket preservation by deproteinized bovine bone graft PROCEDURE

After atraumatic extraction, socket preservation by deproteinized bovine bone and collagen sponge was done and implant placement was performed after four months from that.

Deproteinized bovine

socket preservation by deproteinized bovine bone graft mixed with advanced PRF+ PROCEDURE

After atraumatic extraction, socket preservation by deproteinized bovine bone mixed with advanced PRF+ and collagen sponge was done and implant placement was performed after four months from that.

Deproteinized bovine bone with advanced PRF

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patient with good oral hygiene.
• Age (18-50) years.
• Presence of non-restorable maxillary premolar teeth due to caries, root resorption, roots fracture, etc.
• No history of parafunctional habits
• Adequate inter arch space
• Patients prepared to comply with the follow-up and maintenance program.

You may not qualify if:

• Patients with systemic diseases that interfere with dental implant insertion.
• Smokers.
• Pregnancy.
• Immunocompromised patients.
• Presence of acute infection at the tooth to be extracted

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Faculty of Dentistry Mansoura University

Al Mansurah, Egypt

Location

MeSH Terms

Conditions

Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 4, 2026
• First Posted: October 9, 2026
• Study Start: November 1, 2025
• Primary Completion: April 7, 2026
• Study Completion: September 8, 2026
• Last Updated: October 9, 2026

Record last verified: 2026-10

Locations

EG (1)