Autogenous Demineralized Dentin Block Graft Versus Particulate Deproteinized Bovine Bone Graft for Alveolar Ridge Preservation

NCT05374083 | Unknown

• 1 other identifier: perio2022may
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this trial is to compare the effect of autogenous demineralized dentin block graft (ADDBG) versus particulate deproteinized bovine bone graft (PDBBG) on alveolar ridge preservation after extraction of non-restorable single rooted teeth

Conditions

Alveolar Bone Loss

Outcome Measures

Primary Outcomes (1)

• Alveolar ridge bucco-lingual width change in mm

  Alveolar bone linear width will be measured at baseline and after 6 months using cone beam computed tomography (CBCT) scans. The change in bone width will be calculated as the subtraction of final width from baseline width and will be measured in millimetres

  6 months

Secondary Outcomes (2)

• Alveolar ridge apico-coronal height change in mm

  6 months

• Histological assessment

  6 months

Study Arms (2)

Alveolar ridge preservation using autogenous demineralized dentin block graft

EXPERIMENTAL

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as demineralized dentin block graft and inserted in the extraction socket and covered then suturing

Procedure: Alveolar ridge preservation using autogenous demineralized dentin block graft

Alveolar ridge preservation using particulate deproteinized bovine bone graft

ACTIVE COMPARATOR

Atraumatic extraction of non-restorable teeth, then the socket will be packed by particulate deproteinized bovine bone graft and covered then suturing

Procedure: Alveolar ridge preservation using particulate deproteinized bovine bone graft

Interventions

Alveolar ridge preservation using autogenous demineralized dentin block graft PROCEDURE

Atraumatic extraction of non restorable tooth, then the extracted tooth will be prepared and demineralized by hydrochloric acid (HCL) acid and inserted as demineralized dentin block graft in the socket

Alveolar ridge preservation using autogenous demineralized dentin block graft

Alveolar ridge preservation using particulate deproteinized bovine bone graft PROCEDURE

Atraumatic extraction of non restorable tooth, then the socket will be packed by particulate deproteinized bovine bone

Alveolar ridge preservation using particulate deproteinized bovine bone graft

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Non-restorable tooth indicated for extraction
• Single-rooted teeth
• Motivated patients, agree to sign informed consent and complete the follow-up period

You may not qualify if:

• Pregnant females
• active infection at extraction site
• Smokers
• systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of dentistry

Cairo, Egypt

Location

Related Publications (6)

• Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hammerle CH, Attin T, Schmidlin P. Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial. J Clin Periodontol. 2013 Jan;40(1):90-8. doi: 10.1111/jcpe.12027. Epub 2012 Nov 19.

  PMID: 23163915 BACKGROUND

• Wong RW, Rabie AB. Effect of bio-oss collagen and collagen matrix on bone formation. Open Biomed Eng J. 2010 Mar 9;4:71-6. doi: 10.2174/1874120701004010071.

  PMID: 20461225 BACKGROUND

• Pang C, Ding Y, Zhou H, Qin R, Hou R, Zhang G, Hu K. Alveolar ridge preservation with deproteinized bovine bone graft and collagen membrane and delayed implants. J Craniofac Surg. 2014 Sep;25(5):1698-702. doi: 10.1097/SCS.0000000000000887.

  PMID: 25148644 BACKGROUND

• Barootchi S, Wang HL, Ravida A, Ben Amor F, Riccitiello F, Rengo C, Paz A, Laino L, Marenzi G, Gasparro R, Sammartino G. Ridge preservation techniques to avoid invasive bone reconstruction: A systematic review and meta-analysis: Naples Consensus Report Working Group C. Int J Oral Implantol (Berl). 2019;12(4):399-416.

  PMID: 31781696 BACKGROUND

• Kim, Y., Fajardo, K., Valera, A. and Um, I. (2017) 'Autogenous Tooth Bone Graft Block For Socket Preservation: A One-Stage Technique', Dentistry, 7(414), pp. 2161-1122.1000414.

  BACKGROUND

• Santos A, Botelho J, Machado V, Borrecho G, Proenca L, Mendes JJ, Mascarenhas P, Alcoforado G. Autogenous Mineralized Dentin versus Xenograft granules in Ridge Preservation for Delayed Implantation in Post-extraction Sites: A Randomized controlled clinical trial with an 18 months follow-up. Clin Oral Implants Res. 2021 Aug;32(8):905-915. doi: 10.1111/clr.13765. Epub 2021 Jun 17.

  PMID: 33982320 BACKGROUND

MeSH Terms

Conditions

Alveolar Bone Loss

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

Mohamed Talaat, Master Degree

CONTACT

+201009174617; Mohamed.Talaat@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator. Mohamed Elbehwashy

Study Record Dates

• First Submitted: May 7, 2022
• First Posted: May 16, 2022
• Study Start: July 1, 2022
• Primary Completion: February 1, 2023
• Study Completion: August 1, 2023
• Last Updated: May 16, 2022

Record last verified: 2022-05

Locations

EG (1)