Mineralized Dentin Graft Versus Beta-Tricalcium Phosphate for Alveolar Ridge Preservation

NCT07812610 | Completed

• 1 other identifier: R.26.08.135
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed. Participants were randomly assigned to one of three groups. One group received no bone graft material. One group received mineralized dentin graft made from the participant's extracted tooth. One group received beta-tricalcium phosphate, which is a synthetic bone graft material. Participants had cone-beam computed tomography, a three-dimensional dental X-ray, immediately after tooth removal and again after 6 months. During dental implant placement at 6 months, researchers collected a small bone sample to examine healing.

Conditions

Alveolar Bone Loss

Keywords

Mineralized Dentin Graft; Autogenous Tooth-Derived Graft; Beta-Tricalcium Phosphate; Tooth Extraction; Cone-Beam Computed Tomography; Histomorphometry; Alveolar Ridge Preservation

Outcome Measures

Primary Outcomes (1)

• Change in Alveolar Bone Width From Baseline to 6 Months

  Alveolar bone width was measured in millimeters using cone-beam computed tomography immediately after tooth extraction and at 6 months. Width was measured horizontally from the outer buccal cortical surface to the palatal cortical surface.

  Baseline immediately after tooth extraction and 6 months

Study Arms (3)

Autogenous Mineralized Dentin Graft

EXPERIMENTAL

Following atraumatic tooth extraction, autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket.

Procedure: Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft

Beta-Tricalcium Phosphate

ACTIVE COMPARATOR

Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket.

Procedure: Alveolar Ridge Preservation With Beta-Tricalcium Phosphate

Control: No Bone Graft

ACTIVE COMPARATOR

Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket.

Procedure: Extraction Socket Healing Without Bone Graft

Interventions

Alveolar Ridge Preservation With Beta-Tricalcium Phosphate PROCEDURE

Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket.

Beta-Tricalcium Phosphate

Extraction Socket Healing Without Bone Graft PROCEDURE

Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket.

Control: No Bone Graft

Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft PROCEDURE

Following atraumatic tooth extraction, an autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket.

Autogenous Mineralized Dentin Graft

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 years or older.
• Clinical indication for extraction of a hopeless maxillary tooth.
• No evidence of acute infection at the intended extraction site.
• Willing and able to comply with the scheduled study visits and follow-up procedures.
• Provided written informed consent.

You may not qualify if:

• Systemic disorder known to impair bone metabolism.
• History of radiotherapy involving the head and neck region.
• Pregnancy or lactation.
• Advanced periodontal disease.

Sponsors & Collaborators

• Soaad Tolba Mohammed Tolba Badawi: lead

Study Sites (1)

Faculty of Dentistry, Mansoura University

Al Mansurah, Aldakhlia, 35516, Egypt

Location

MeSH Terms

Conditions

Alveolar Bone Loss

Interventions

beta-tricalcium phosphate; Bone Transplantation

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Tissue Transplantation; Cell- and Tissue-Based Therapy; Biological Therapy; Therapeutics; Orthopedic Procedures; Surgical Procedures, Operative; Transplantation

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants and the radiographic and histomorphometric outcome assessors were masked to group assignment. The statistician was also masked. The operating surgeon could not be masked and learned the group assignment after tooth extraction when the sealed allocation envelope was opened.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer of Oral and Maxillofacial Surgery

Model Details: Three-arm, parallel-group randomized controlled trial in which extraction sites were allocated in a 1:1:1 ratio to healing without bone graft material, autogenous mineralized dentin graft, or beta-tricalcium phosphate.

Study Record Dates

• First Submitted: September 4, 2026
• First Posted: September 10, 2026
• Study Start: January 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 1, 2026
• Last Updated: September 17, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)