Autogenous Demineralized Dentin Graft Combined With Injectable PRF + Metronidazole Versus Autogenous Demineralized Dentin Graft Combined With Injectable PRF Versus Autogenous Demineralized Dentin Graft Alone for Alveolar Ridge Preservation

NCT06374784 | Completed

• 1 other identifier: perio2023ARP
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this trial is to compare the effect of autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole (sticky demineralized tooth releasing metronidazole) versus autogenous demineralized dentin graft combined with injectable PRF (sticky demineralized tooth) versus autogenous demineralized dentin graft (ADDG) alone on alveolar ridge preservation after extraction of non restorable, infected single-rooted teeth

Conditions

Alveolar Bone Loss

Outcome Measures

Primary Outcomes (1)

• buccal ridge height change in mm

  Difference in height linear measurements between baseline and final CBCT scans

  6 months

Secondary Outcomes (5)

• Alveolar ridge bucco-lingual width change in mm

  6 months

• Histomorphometric analysis

  6 months

• palatal ridge height change in mm

  6 months

• the need for additional augmentation during implant placement

  6 months

• patient discomfort and pain

  7 days postoperatively

Study Arms (3)

Alveolar ridge preservation using demineralized dentin combined with I-PRF + metronidazole

EXPERIMENTAL

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft and processed with injectable platelet rich fibrin. The injectable PRF will be mixed with 5mg/ml metronidazole first then added to the particulate demineralized dentin graft then inserted in the extraction socket and covered then suturing

Procedure: Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole

Alveolar ridge preservation using demineralized dentin combined with I-PRF

EXPERIMENTAL

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft. The injectable PRF will be mixed with the particulate demineralized dentin graft then inserted in the extraction socket and covered then suturing

Procedure: Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF

Alveolar ridge preservation using autogenous demineralized dentin graft alone

ACTIVE COMPARATOR

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft and inserted in the extraction socket and covered then suturing

Procedure: Alveolar ridge preservation using autogenous demineralized dentin graft alone

Interventions

Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF PROCEDURE

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft. The injectable PRF will be added to the particulate demineralized dentin graft forming sticky demineralized tooth graft then inserted in the extraction socket and covered then suturing

Alveolar ridge preservation using demineralized dentin combined with I-PRF

Alveolar ridge preservation using autogenous demineralized dentin graft alone PROCEDURE

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid inserted in the extraction socket as particulate demineralized dentin graft

Alveolar ridge preservation using autogenous demineralized dentin graft alone

Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole PROCEDURE

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft and processed with injectable platelet rich fibrin. The injectable PRF will be mixed with 5mg/ml metronidazole first then added to the particulate demineralized dentin graft forming sticky demineralized tooth graft with slowly released metronidazole then inserted in the extraction socket and covered then suturing

Alveolar ridge preservation using demineralized dentin combined with I-PRF + metronidazole

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Non-restorable tooth indicated for extraction in esthetic maxillary zone
• Anterior or premolar teeth
• Apical chronic pathosis
• Motivated patients, agree to sign informed consent and complete the follow-up period
• FMPS of \<15% and a FMBS \<10%

You may not qualify if:

• Pregnant or lactating females
• Active infection at extraction site
• Smokers
• Systemic conditions affecting healing (e.g. diabetes, Paget disease or hyperthyroidism, medications as bisphosphonates...)

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Dentistry

Cairo, Egypt

Location

Related Publications (4)

• Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hammerle CH, Attin T, Schmidlin P. Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial. J Clin Periodontol. 2013 Jan;40(1):90-8. doi: 10.1111/jcpe.12027. Epub 2012 Nov 19.

  PMID: 23163915 BACKGROUND

• Elfana A, El-Kholy S, Saleh HA, Fawzy El-Sayed K. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021 May;32(5):539-548. doi: 10.1111/clr.13722. Epub 2021 Mar 1.

  PMID: 33565656 BACKGROUND

• van Orten A, Goetz W, Bilhan H. Tooth-Derived Granules in Combination with Platelet-Rich Fibrin ("Sticky Tooth") in Socket Preservation: A Histological Evaluation. Dent J (Basel). 2022 Feb 16;10(2):29. doi: 10.3390/dj10020029.

  PMID: 35200254 BACKGROUND

• Elbehwashy MT, Hosny MM, Elfana A, Saleh HA, Fawzy El-Sayed K. Autogenous Demineralized Dentin Graft-Based Strategies With or Without I-PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial. J Periodontal Res. 2026 Feb 20. doi: 10.1111/jre.70092. Online ahead of print.

  PMID: 41717869 DERIVED

MeSH Terms

Conditions

Alveolar Bone Loss

Interventions

Metronidazole

Condition Hierarchy (Ancestors)

Bone Resorption; Bone Diseases; Musculoskeletal Diseases; Periodontal Atrophy; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Nitroimidazoles; Nitro Compounds; Organic Chemicals; Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator. Mohamed Elbehwashy

Study Record Dates

• First Submitted: April 16, 2024
• First Posted: April 19, 2024
• Study Start: May 20, 2024
• Primary Completion: May 2, 2025
• Study Completion: June 28, 2025
• Last Updated: December 15, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)