Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.

NCT07855549 | Enrolling By Invitation DMC

• 1 other identifier: thoracic surgery analgesia
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries.

Conditions

Post Operative Pain; Thoracic Surgery

Keywords

Nerve block in thoracic surgery

Outcome Measures

Primary Outcomes (1)

• First analgesic request

  The time of first request to analgesia by patient post operative

  24 hours

Study Arms (3)

Erector spinae group

ACTIVE COMPARATOR

Sonar guided interfacial plane block deep to erector spinae muscle that targets dorsal and central Rami of spinal nerves

Procedure: Erector spinae plane block

Combined pectoralis and serratus anterior group

ACTIVE COMPARATOR

Sonar guided interfacial plane blocks firstly pectoralis plane block that targets lateral and medial pectoral nerves then serratus anterior plane block that targets lateral branches of intercostal nerves

Procedure: Combined pectoralis and serratus anterior plane blocks

Controlled group

NO INTERVENTION

This group doesn't receive any nerve block

Interventions

Erector spinae plane block PROCEDURE

Patients will be positioned in the lateral position, The thoracic vertebrae spinous process convenient to level of incision (T5-T7:the level which covers thoracic area) will be identified and the transducer will be placed approximately to 2-3 cm lateral to midline ,The needle tip will be advanced until it is located in the interfascial plane deep to the erector spinae muscle group and superior to the transverse process. Once in position, 30 ml bupivacaine 0.25% will be injected under ultrasound guidance. Correct needle-tip position will be confirmed by the presence of linear spread between the transverse process and the presence of linear spread between the transverse process and the erector spinae muscle group.

Also known as: ESPB

Erector spinae group

Combined pectoralis and serratus anterior plane blocks PROCEDURE

Serratus anterior plane block will be performed with the patient in the supine position , The probe will be placed in a sagittal position, the mid-axillary region of the thoracic cage. The needle will be advanced with an in-plane technique and 20 ml bupivacaine 0.25% will be injected . PECS block will be performed at the same position. The ultrasound probe will be placed obliquely over the lateral third of the clavicle. the needle will be advanced, in the same plane as the probe, from the medial to lateral direction ,10 ml 0.25% bupivacaine will be injected. Then the needle will be advanced to the fascial plane between the pectoralis minor and serratus anterior muscles, at which point an additional 10 ml 0.25% bupivacaine will be administered.

Also known as: PECS &SAPB

Combined pectoralis and serratus anterior group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• body mass index (BMI) from 20 - 35 kg/m2, ASA physical status I\&II

You may not qualify if:

• Patients with signs of active infection or infection at the site of block placement.
• Refusal of consent. History of any motor or sensory deficits as peripheral neuropathy, history of stroke with residual muscle weakness, multiple sclerosis, pre-existing sensory loss as diabetic neuropathy, spinal cord injury, spine abnormalities as kypholordosis.
• Hypersensitivity or allergy to the drugs used for block. Patients with coagulopathy or on anticoagulant therapy. Extended incision not covered by the block (posterior or medial extended incision).

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Minya university

Minya, Minya Governorate, 61511, Egypt

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Saposins

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Sphingolipid Activator Proteins; Coenzymes; Enzymes and Coenzymes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Aya Sedeek Mostafa

Study Record Dates

• First Submitted: September 28, 2026
• First Posted: October 2, 2026
• Study Start: April 1, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: October 2, 2026

Record last verified: 2025-11

Locations

EG (1)