NCT07788027|RecruitingDMC
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Sponsor study identifier
interventional
32
1 country
1
Study Start
April 14, 2026
Actual (reported)Primary Completion
April 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 14, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The main aim of endodontic therapy is to disinfect the entire root canal system (RCS), which requires the elimination of microorganisms and microbial components. This goal is pursued by chemo-mechanical debridement of the RCS. Attaining this goal remains challenging due to the complex and variable anatomy of the root canal system, which includes intricate structures such as fins, isthmuses, lateral canals, and apical deltas that are often inaccessible to mechanical instrumentation. To overcome these anatomical limitations, various irrigation protocols have been developed to enhance the penetration and effectiveness of irrigating solutions.The use of different activation techniques-such as manual dynamic agitation, irrigation needle, sonic and ultrasonic activation, and negative pressure irrigation systems-aims to improve the distribution, exchange, and cleaning ability of irrigants within hard-to-reach areas of the canal system.These approaches are designed to maximize microbial reduction and promote more effective removal of debris and smear layer remnants.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 14, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 14, 2026
Actual (reported)August 16, 2026
Actual (reported)August 26, 2026
Actual (reported)April 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
April 14, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Post-operative pain
Postoperative pain will be assessed using a 10-cm Visual Analog Scale (VAS), where 0 will indicate "no pain" and 10 will indicate "worst imaginable pain." Participants will be instructed to record their pain intensity at 6, 12, 24, 48,and 72 hours, and on the 7th day after treatment. All recorded pain scores will be collected for statistical analysis and comparison among the study groups
7 Days
About 8 cases will have Endodontic treatment of single-rooted teeth irrigated with Sodium hypochlorite (NaOCl) 5.25% as irrigating solution used as 20 mL irrigant per canal \& EDDY sonic activation tips (Device)
About 8 cases will have Endodontic treatment of single-rooted teeth irrigated with Sodium hypochlorite (NaOCl) 5.25% \& Apical Negative Pressure Irrigation using Safe Clean system
to compare the effect of all different irrigation and activation protocols manual agitation, conventional needle irrigation, sonic activation, and negative pressure systems (such as Safe Clean) on the incidence and intensity of postoperative pain following endodontic treatment of canines and premolars
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Endodontics Department Faculty of Dentistry
Minya, Egypt
Dalia Ali Ahmed Moukarab, M.D
Professor and Head of the Endodontics Department, Faculty of Dentistry
First Submitted
August 16, 2026
First Posted
August 26, 2026
Study Start
April 14, 2026
Actual (reported)Primary Completion
April 1, 2027
EstimatedPostoperative Pain After Pulpectomy of Primary Molars
About 8 cases will have Endodontic treatment of single-rooted teeth irrigated with Sodium hypochlorite (NaOCl) 5.25% \& manual agitation technique with apical master gutta percha cone (Device)
About 8 cases will have Endodontic treatment of single-rooted teeth irrigated with Sodium hypochlorite (NaOCl) 5.25% \& side vented needle (Device)
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
April 14, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 26, 2026
Record last verified: 2026-04
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Source: ClinicalTrials.gov.
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