NCT07854119

Brief Summary

Upper Cross Syndrome (UCS) is a prevalent musculoskeletal disorder characterized by a specific pattern of muscular imbalance and postural dysfunction. This condition arises from prolonged poor posture. The resulting imbalance often manifests as visible postural changes, including rounded shoulders, forward head posture, and increased thoracic kyphosis. UCS is characterized by tightness and weakness of the neck, shoulders, and upper back muscles that cross between the dorsal and the ventral sides of the body. Postural abnormalities associated with UCS include a forward head posture (FHP), cervical lordosis, thoracic hyper kyphosis, protracted and elevated shoulders (round shoulders), and scapular winging with increased internal rotation and abduction. In UCS, neck and chest muscles, such as the sternocleidomastoid (SCM), levator scapulae, Pectoralis major and minor, Scalenes, and Upper Trapezius (UT), are tightened or shortened, whereas muscles of the neck and posterior upper back, such as the Deep Neck Flexors (DNFs), Serratus Anterior (SA), Rhomboids, Middle Trapezius (MT), and Lower Trapezius (LT), are weakened, stretched, and restrained. Opposite-group muscle imbalances in UCS bring postural disturbances, misalignments in the upper limbs, and atlanto-occipital, cervicothoracic, and glenohumeral joint dysfunction. The muscular imbalances may also lead to various musculoskeletal symptoms, such as headaches, neck pain, chest pain, upper back pain, tingling in the upper arms, or a limited range of motion in the neck or shoulders. The alteration in scapula muscles in UCS affects the movement of the scapula, which acts as a bridge and provides mobility and stability to the shoulders and neck. A proper posture is necessary for optimal functional performance in daily activities. The awkward positions put constant pressure on the joints, and degenerative changes in joints progress rapidly when exposed to sustained pressure, causing muscle imbalances and pain. If a muscle imbalance continues and progresses, this may lead to altered movement patterns and joint damage, creating further dysfunction. The main risk factor for developing UCS is maintaining an abnormal posture for a prolonged duration. Some daily activities that involve bad postures are often occupation-related. Repetitive tasks or continuous work for long hours can aggravate postural deviations. For example, patients with improper postures are more prone to musculoskeletal injuries after handling or lifting heavy objects than others with a proper posture. Musculoskeletal pain, most commonly neck pain, may present as the main symptom of UCS. Musculoskeletal pain may increase in relation to standing continuously or improperly sitting for long hours.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
2mo left

Started Jun 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress68%
Jun 2026Dec 2026

Study Start

First participant enrolled

June 1, 2026

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 27, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 2, 2026

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

October 2, 2026

Status Verified

September 1, 2026

Enrollment Period

5 months

First QC Date

September 27, 2026

Last Update Submit

September 27, 2026

Conditions

Keywords

Upper Cross SyndromeKendall exercisesPositional Release TechniquesCraniovertebral anglePainRange of Motion

Outcome Measures

Primary Outcomes (3)

  • Numeric Pian Rating Scale

    Numeric Pain Rating Scale (NPRS). It is a uni-dimensional scale to measure pain intensity, particularly in adults. It is a 10-rating scale and an 11-point numeric scale in the form of a horizontal bar or line. Zero is no pain, and 10 is intolerable/worst pain.

    Baseline; Week 3; Week 6

  • Neck Diability Index (NDI)

    This questionnaire will be used to assess disability. It comprises of 10 items; 7 related to daily living activities, 2 related to pain and 1 related to concentration. Each item is scored from 0 to 5. Total score is expressed as a percentage, with higher scores related to greater disability

    Baseline; Week 3; Week 6

  • Craniovertebral Angle

    The craniovertebral angle (CVA) is a commonly used clinical indicator for evaluating forward head posture, which is a prominent feature of Upper Crossed Syndrome (UCS). It is measured by drawing a horizontal line through the spinous process of the seventh cervical vertebra (C7) and a second line from C7 to the tragus of the ear. A smaller CVA reflects a greater degree of forward head posture, with angles less than 50 degrees typically considered abnormal

    Baseline; 3 Week; 6 Week

Study Arms (2)

Group A

EXPERIMENTAL

Kendall Exercises with Positional Release Therapy

Other: Kendall Exercises with Positional Release Therapy

Group B

ACTIVE COMPARATOR

Kendall Exercises

Other: Kendall Exercises

Interventions

Kendall's exercises and the Positional Release Technique (PRT) offer complementary physical therapy approaches for managing Upper Cross Syndrome. Kendall's framework, grounded in manual muscle testing and detailed postural analysis, restores alignment by pairing selective strengthening of weak muscles with selective stretching of tight ones. Its protocol incorporates chin tucks, shoulder blade squeezes, scapular depression, chest stretches, wall slides, and thoracic extensions. Exercises are executed in 3-6 sets of 10-15 reps, holding each for 10 seconds to enhance scapular control and correct forward head posture. Conversely, PRT-developed by Dr. Lawrence Jones-is an indirect soft-tissue therapy aimed at reducing muscle spasms and hypertonicity without stretching. Clinicians identify tender points and passively position the tissue into a shortened state of ease, holding it for 90 seconds to reset muscle spindle activity before returning to neutral.

Group A

Kendall's exercises, derived from the foundational work of Florence and Henry Kendall, provide a targeted physical therapy framework for addressing Upper Cross Syndrome through precise postural analysis and manual muscle testing. The core strategy centers on correcting muscle imbalances by selectively strengthening inhibited, weak muscles while stretching tight, shortened ones to restore proper posture and alignment. To counteract forward head posture and scapular dysfunction, the protocol incorporates chin tucks to strengthen deep cervical flexors, prone shoulder blade squeezes for middle trapezius and rhomboids, and scapular depression or retraction for lower and upper trapezius control. Flexibility is restored using doorway stretches for tight pectoralis muscles, along with targeted stretches for the upper trapezius and levator scapulae. Wall slides and foam roller thoracic extension further improve scapular movement and spine mobility. Exercises are routinely performed for 3 to 6

Group B

Eligibility Criteria

Age20 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age 20 and 40 years.
  • Both Male and Female.
  • Clinical diagnosis of Upper Crossed Syndrome (Pectoralis major contracture test, Pectoralis minor contracture test, Upper trapezius muscle length test, Lower and Middle trapezius weakness tests will be done).
  • Forward Head Posture (Craniovertebral angle (CVA) ≤ 48°).
  • Numeric Pain Rating Scale (NPRS) score of ≥ 4).
  • Neck pain for more than 4 weeks but less than 6 months NDI.

You may not qualify if:

  • History of cervical spine trauma, fractures, or surgery
  • Systemic musculoskeletal disorders
  • Spinal Deformities
  • Ongoing physiotherapy or chiropractic treatment
  • Severe scoliosis or spinal deformities

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Riphah Rehabilitation Clinic

Lahore, Punjab Province, 54000, Pakistan

RECRUITING

Riphah International University

Lahore, 54000, Pakistan

RECRUITING

Related Publications (5)

  • Mujawar JC, Sagar JH. Prevalence of Upper Cross Syndrome in Laundry Workers. Indian J Occup Environ Med. 2019 Jan-Apr;23(1):54-56. doi: 10.4103/ijoem.IJOEM_169_18.

    PMID: 31040591BACKGROUND
  • Khosravi Z, Mohammad Ali Nasab Firouzjah E, Firouzjah MH. Comparison of balance and proprioception of the shoulder joint in girls with and without upper cross syndrome. BMC Musculoskelet Disord. 2024 Aug 2;25(1):618. doi: 10.1186/s12891-024-07552-5.

    PMID: 39095725BACKGROUND
  • Zhang C, Zhang J, Yang G. Association between internet addiction and the risk of upper cross syndrome in Chinese college students: A cross sectional study. Medicine (Baltimore). 2023 Jul 28;102(30):e34273. doi: 10.1097/MD.0000000000034273.

    PMID: 37505162BACKGROUND
  • Shaheen A, Kazim H, Eltawil M, Aburukba R. IoT-Based Solution for Detecting and Monitoring Upper Crossed Syndrome. Sensors (Basel). 2023 Dec 26;24(1):135. doi: 10.3390/s24010135.

    PMID: 38202995BACKGROUND
  • Firouzjah MH, Firouzjah EMAN, Ebrahimi Z. The effect of a course of selected corrective exercises on posture, scapula-humeral rhythm and performance of adolescent volleyball players with upper cross syndrome. BMC Musculoskelet Disord. 2023 Jun 14;24(1):489. doi: 10.1186/s12891-023-06592-7.

    PMID: 37316911BACKGROUND

MeSH Terms

Conditions

Oculocerebral hypopigmentation syndrome type PreusPain

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Syed Shakil ur Rehman, PhD

    Riphah International University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Syed Shakil ur Rehman, PhD Physical Therapy

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 27, 2026

First Posted

October 2, 2026

Study Start

June 1, 2026

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

October 2, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will not share

Locations