NCT07372391

Brief Summary

Upper Crossed Syndrome (UCS) is a widespread muscle imbalance defined by tightness in the upper trapezius, pectoralis major and minor, and sternocleidomastoid, coupled with weakness in deep neck flexors, lower trapezius, and serratus anterior. It is usually triggered by sustained faulty posture, predominantly in computer users, drivers, or other prolonged forward head and trunk flexion positions, resulting in pain, fatigue, limited ROM and functional limitations. On a global scale, estimates suggest that UCS affects between 11% and 60% of individuals, spanning various age groups and cultural backgrounds. Individuals who engage in prolonged slouching, such as desk workers, teachers, drivers, IT professionals, students, and laundry workers, demonstrate prevalence rates of approximately 32.4%, 16.2%, 26.4%, 67%, 37.1%, and 28% respectively. Janda's approach, aims to restore or normalize muscle balance and refine posture by combining stretching of tight and overactive muscles with strengthening of weak and inhibited muscles, in sequence. Instrument-Assisted Soft Tissue Mobilization (IASTM) enhances ROM and alleviates pain by directing myofascial restrictions. As adjuncts, hot packs and transcutaneous electrical nerve stimulation (TENS) are frequently used to reduce discomfort and prepare tissues for further therapeutic interventions. Although numerous intervention techniques are offered for UCS but limited research has compared Janda's approach and IASTM, especially with respect to their impact on fatigue. Therefore, this study aims to evaluate and compare the effects of these interventions on pain, fatigue, and posture in adults with UCS.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2025

Completed
21 days until next milestone

First Submitted

Initial submission to the registry

January 20, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 28, 2026

Completed
Last Updated

January 28, 2026

Status Verified

January 1, 2026

Enrollment Period

6 months

First QC Date

January 20, 2026

Last Update Submit

January 20, 2026

Conditions

Keywords

Janda's ApproachInstrument Assisted Soft Tissue Mobilization (IASTM)Upper Cross Syndrome (UCS)PainFatiguePosture

Outcome Measures

Primary Outcomes (3)

  • Pain Intensity

    Pain intensity measured using the Numeric Pain Rating Scale (NPRS), an 11-point scale rating from 0 (no pain) to 10 (worst pain).

    Baseline, Post-intervention 2 weeks, Post-intervention 4 weeks

  • Fatigue

    Fatigue assessed using the Fatigue Severity Scale (FSS), a 9-item self-report questionnaire in which each item is scored on a 7-point Likert scale, with higher scores indicating greater fatigue severity.

    Baseline, Post-intervention 2 weeks, Post-intervention 4 weeks

  • Posture

    REEDCO Posture Assessment Scale was employed to evaluate postural alignment in individuals with Upper Crossed Syndrome, focusing specifically on the head, shoulder, and upper back regions. These items were selected as they directly correspond to the primary postural deviations associated with the syndrome, namely forward head posture, rounded shoulders, and increased thoracic kyphosis. Scoring was based on established REEDCO criteria, a score of 10 (normal alignment or good posture), a score of 5 (minimal to moderate deviation or fair posture), and a score of 0 (marked or severe deviation or poor posture)

    Baseline, Post-intervention 2 weeks, Post-intervention 4 weeks

Study Arms (2)

Janda Group

EXPERIMENTAL

Participants in this arm received Janda's Approach that specifically targets functional muscular imbalance through stretching, strengthening and sensorimotor training.

Other: Janda's Approach

IASTM Group

ACTIVE COMPARATOR

Participants in this arm received Instrument Assisted Soft Tissue Mobilization through graston tool.

Other: Instrument Assisted Soft Tissue Mobilization (IASTM)

Interventions

All programs will be performed 3 times per week for 4 weeks. Each session will be of 45 minutes. 15 minutes warm up, 10 minutes cool down with 20 minutes stretching and isometrics along with sensorimotor training. Static stretching will be performed holding the stretch for at least 15 sec. and isometric exercise will be conducted three times in a maximum contraction mode for 3 sec under the supervision of a certified expert. Sensorimotor training includes following tasks chin tuck ins, scapular setting, wall alignment drills, diagonal arm patterns.

Janda Group

It will be performed 3 times per week for 4 weeks. Each treatment session will be of 45 minutes. 15 minutes Warm up and 10 minutes cool down period and 20 mins application of IASTM assisted by gel or oil to make it friction free. Icing will be applied at end of each session to reduce post treatment inflammation.

IASTM Group

Eligibility Criteria

Age19 Years - 44 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Participants aged between 19-44 years (Adults), both genders
  • Pectoralis major and Upper trapezius tightness, Serratus anterior and Lower trapezius weakness
  • Forward Head Posture (developed within 6 weeks or more than 3 months)
  • Reported neck, upper back, or shoulder pain or discomfort
  • Pain 5 or above on NPRS for at least 3 months
  • Fatigue score of 4 or above on Fatigue Severity Scale

You may not qualify if:

  • Congenital anomalies
  • Thoracic Outlet Syndrome
  • Inflammatory disorders
  • Headache due to any cause (migraine, disc bulge)
  • Postural defects (Torticollis, Scoliosis)
  • Malignancy
  • Fracture of cervical spine and clavicle

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Biological and Applied Sciences, Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Oculocerebral hypopigmentation syndrome type PreusPainFatigue

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Lecturer

Study Record Dates

First Submitted

January 20, 2026

First Posted

January 28, 2026

Study Start

July 1, 2025

Primary Completion

December 30, 2025

Study Completion

December 30, 2025

Last Updated

January 28, 2026

Record last verified: 2026-01

Locations