Role of Total Thyroidectomy in Relieving Local Symptoms in Hashimoto's Thyroiditis

NCT07852026 | Not Yet Recruiting

• 1 other identifier: Hashimoto's Thyroiditis
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management.

Conditions

Hashimoto Thyroiditis; Goiter

Keywords

Total Thyroidectomy; Hashimoto's Thyroiditis; Compressive Symptoms; Thyroid Surgery

Outcome Measures

Primary Outcomes (1)

• Improvement or Relief of Local Compressive Symptoms

  Assessment of changes in patient-reported compressive symptoms (such as dysphagia, dyspnea, and local neck discomfort or pressure) following total thyroidectomy compared to baseline status.

  6 months postoperatively

Secondary Outcomes (1)

• Incidence of Postoperative Complications

  Up to 30 days postoperatively

Interventions

Total Thyroidectomy PROCEDURE

Surgical removal of the entire thyroid gland performed under general anesthesia for patients with Hashimoto's thyroiditis presenting with compressive or local neck symptoms.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with Hashimoto's thyroiditis who suffer from persistent local compressive symptoms and undergo total thyroidectomy at the Department of Surgery, Assiut University Hospitals.

You may qualify if:

• Adults patients with confirmed Hashimoto's thyroiditis (elevated serum anti-thyroid peroxidase \\anti-thyroglobulin antibodies, characteristic ultrasound findings and/or positive fine needle aspiration cytology)
• Biochemically euthyroid with normal thyroid function test.
• Presence of persistent local symptoms (neck pain, throat discomfort,neck tightness,chocking) for more than 6 months
• Patient fit and motivated to surgery.

You may not qualify if:

• Confirmed or high-suspicion thyroid malignancy (Bethesda V or IV on FNAC
• Previous thyroid or neck surgery
• Patient refusal to participate in the study
• Severe comorbidities precluding general anesthesia
• Active psychiatric illness

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University Hospitals

Asyut, Asyut Governorate, 71515, Egypt

Location

MeSH Terms

Conditions

Hashimoto Disease; Goiter

Condition Hierarchy (Ancestors)

Thyroiditis, Autoimmune; Thyroiditis; Thyroid Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Ahmed Gamal Hamdan, Lecturer

  STUDY DIRECTOR

Central Study Contacts

Ahmed Atef Muslim, Bachelor of Medicine and Surge

CONTACT

+201099626447; ahmed.atef.465.aa@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: September 25, 2026
• First Posted: October 1, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): June 1, 2028
• Last Updated: October 1, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)