Predictive Factors for Medullary Thyroid Cancer Aggressiveness

NCT06292988 | Completed DMC

• 1 other identifier: MYELO
• Study Type: observational
• Target: 500
• Locations: 24 countries
• Sites: 46

Brief Summary

This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.

Conditions

Medullary Thyroid Cancer

Outcome Measures

Primary Outcomes (3)

• Central lymph node metastasis

  Central neck compartment lymph node metastasis

  Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively

• Lateral lymph node metastasis

  Lateral neck compartment lymph node metastasis

  Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively

• Distant metastasis

  Liver and lung metastasis

  Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively

Secondary Outcomes (10)

• Nuclear atypia as histological predictor of aggressiveness

  The pathology report is held immediately after surgery

• Amyloid as histological predictor of aggressiveness

  The pathology report is held immediately after surgery

• Immunohistochemistry as histological predictor of aggressiveness

  The pathology report is held immediately after surgery

• Desmoplasia as histological predictor of aggressiveness

  The pathology report is held immediately after surgery

• CEA as Biochemical predictor of aggressiveness

  pre and postoperative laboratory exams up to 1 year postoperatively

Interventions

Total Thyroidectomy PROCEDURE

Total thyroidectomy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients \>18 years old who underwent surgery for medullary thyroid cancer are enrolled in this study

You may qualify if:

• Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection

You may not qualify if:

• Age \< 18 years

Sponsors & Collaborators

• Aristotle University Of Thessaloniki: lead

Study Sites (46)

Oregon Health & Science University, Oregon

Oregon City, Oregon, 97239, United States

Location

Department of Surgery, Saint John of God Hospital, Salzburg, Austria

Salzburg, Austria

Location

Saint Luc, University Clouvain, Belgium

Brussels, Belgium

Location

Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil

Santa Cruz do Sul, Brazil

Location

University Clinic of Surgery, University Hospital "Lozenec"

Sofia, Bulgaria

Location

Chinese University of Hong Kong

Hong Kong, China

Location

Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia

Manizales, Colombia

Location

the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery

Zagreb, Croatia

Location

Head and Neck Surgery, Brest University Hospital, Brest, France

Brest, France

Location

The University Hospital of Poitiers, France

Poitiers, France

Location

Thyroid Surgery Clinic IKE, Athens, Greece

Athens, Greece

Location

ENT Department University Hospital of Larissa

Larissa, Greece

Location

Department of Surgery, General University Hospital of Patras

Pátrai, Greece

Location

Aristotle University of Thessaloniki

Thessaloniki, Greece

Location

Gennimatas General Hospital

Thessaloniki, Greece

Location

Department of ENT-Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar

Bhubaneswar, India

Location

KMCH and KMCH Comprehensive Cancer Center

Coimbatore, India

Location

Department of Endocrine and Breast Surgery at Sanjay Gandhi Post Graduate Institute of Medical Sciences

Madurai, India

Location

Department of Surgery, Maulana Azad Medical College & Lok Nayak Hospital

New Delhi, India

Location

Endocrine and Metabolic Surgery, Bhargav Endocrine Hospital, Vijayawada, India

Vijayawada, India

Location

University of Sulaimani | UNIVSUL ,Department of Surgery, Kurdistan

Erbil, Iraq

Location

ASL VCO - San Biagio Hospital - Domodossola (VB) - Italy

Domodossola, Italy

Location

Dipartimento di Scienze Chirurgiche (DISC), University of Genoa, Italy

Genoa, Italy

Location

Asst Santi Paolo e Carlo - Ospedale Polo Universitario San Paolo, Milan, Italy

Milan, Italy

Location

UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A Gemelli IRCCS

Roma, Italy

Location

Department of Medical and Surgical Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste, Italy

Trieste, Italy

Location

Department of Surgery and Oncology, Endocrine Surgery Unit, Verona University Hospital

Verona, Italy

Location

Hashemite University of Zarqa

Zarqa, Jordan

Location

Hepatobiliairy and endocrine surgery, Ibn Sina Hospital, Medical School of Medecine Rabat, Mohamed Vth University of Rabat Morocco

Marrakesh, Morocco

Location

Division of General, Endocrine and Transplant Surgery, Medical University of Gdańsk

Gdansk, Poland

Location

Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Medical School, University of Belgrade

Belgrade, Serbia

Location

Comenius University in Bratislava, Department of Paediatric Surgery, National Institute of Children's Diseases

Bratislava, Slovakia

Location

Department of oncological surgery, St. Elisabeth cancer Institute

Bratislava, Slovakia

Location

Hospital Clinic (Barcelona, Spain)

Barcelona, Spain

Location

Universitaria de Cordoba

Córdoba, Spain

Location

Hospital Regional de Málaga

Málaga, Spain

Location

Department of General and Digestive Surgery, Division of Endocrine Surgery, Complexo Hospitalario Universitario de Vigo, Vigo, Spain

Vigo, Spain

Location

Bern University Hospital

Bern, Switzerland

Location

Geneva University Hospital

Geneva, Switzerland

Location

Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok, Thailand

Bangkok, Thailand

Location

Ankara University Faculty of Medicine, Department of Endocrine Surgery

Ankara, Turkey (Türkiye)

Location

Acibadem MAA University

Istanbul, Turkey (Türkiye)

Location

Cerrahpasa medical faculty endocrine surgery department

Istanbul, Turkey (Türkiye)

Location

Department of Endocrin Pathology Unit, University of Health Sciences, Faculty of Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Istanbul, Turkey (Türkiye)

Location

Endocrine surgeon-consultant, International medical center "CITIDOCTOR"

Kyiv, Ukraine

Location

Department of Radiology, Thien Hanh Hospital, Buon Ma Thuot, Vietnam

Việt Trì, Vietnam

Location

MeSH Terms

Conditions

Carcinoma, Medullary

Condition Hierarchy (Ancestors)

Carcinoma, Neuroendocrine; Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms, Ductal, Lobular, and Medullary; Neoplasms, Nerve Tissue

Study Officials

• Theodossis Papavramidis, Prof

  1st Propedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Greece

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 19, 2024
• First Posted: March 5, 2024
• Study Start: March 1, 2024
• Primary Completion: April 15, 2024
• Study Completion: April 15, 2024
• Last Updated: January 3, 2025

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

GR (5); VN (1); SL (2); TH (1); TU (4); FR (2); JO (1); US (1); IR (1); IT (6); PL (1); MO (1); BR (1); CR (1); CO (1); ES (4); UA (1); BE (1); AU (1); CH (2); CN (1); BU (1); SE (1); IN (5)