Incidental Thyroid Cancer in Cases With Inflammatory Thyroid Lesion

NCT07652450 | Completed

• 1 other identifier: 1462/02/2025
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study aim to assess for the incidence of thyroid cancer in patients with autoimmune thyroiditis (Inflammatory thyroid Lesions)

Conditions

Papillary Thyroid Cancer; Hashimoto Disease; Hashimoto's Thyroiditis; Follicular Thyroid Cancer

Keywords

Incidental Thyroid Cancer; Autoimmune Thyroiditis; Hashimoto Thyroiditis; Differentiated Thyroid Cancer; Papillary Thyroid Carcinoma

Outcome Measures

Primary Outcomes (1)

• • Incidence of incidental differentiated thyroid cancer with autoimmune thyroiditis

  Title: Incidence of incidental differentiated thyroid cancer Unit of measure: % of patients (proportion) Metric/method: Histopathological examination of surgical specimen

  At time of surgery (postoperative histopathology)

Secondary Outcomes (8)

• Incidence of incidental differentiated thyroid cancer by autoimmune thyroiditis subtype

  At time of surgery

• Outcome 3A: Age comparison

  At time of surgery

• Outcome 3B: Sex distribution

  Preoperative (within 30 days before surgery)

• Secondary Outcome 4 - Tumor characteristics Outcome 4A: Tumor size

  At time of surgery

• Outcome 4B: Microcarcinoma proportion

  At time of surgery

Study Arms (1)

Inflammatory thyroid lesions

OTHER

The presence of thyroiditis was determined considering histological diagnosis taken post-surgery, and we considered the correlation between any presence of thyroiditis and all Differentiated thyroid cancer, taken from the histopathological examination after pathologic analysis.

Other: total thyroidectomy

Interventions

total thyroidectomy OTHER

Diagnosis of differentiated thyroid cancer: The presence of thyroid cancer was determined based on histopathological examination of the resected specimen

Inflammatory thyroid lesions

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• All types of autoimmune thyroiditis, including:
• Graves' disease
• Toxic multinodular goiter (TMNG)
• Toxic nodule (TN)
• Hashimoto thyroiditis
• Unspecified toxic nodular goiter
• Age between 18 and 60 years
• Underwent thyroid surgical operation (lobectomy or total thyroidectomy)

You may not qualify if:

• Patients with known differentiated thyroid cancer before surgery
• Recurrent thyroid disease (previous thyroid surgery)
• Patients unfit for operation (American Society of Anesthesiologists grade IV or V)
• Incomplete histopathological data
• Patients with medullary thyroid carcinoma or anaplastic thyroid cancer

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Faculty of medicine

Minya, Minya Governorate, 61611, Egypt

Location

MeSH Terms

Conditions

Thyroid Cancer, Papillary; Hashimoto Disease; Adenocarcinoma, Follicular; Thyroiditis, Autoimmune

Condition Hierarchy (Ancestors)

Adenocarcinoma, Papillary; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Thyroid Neoplasms; Endocrine Gland Neoplasms; Neoplasms by Site; Head and Neck Neoplasms; Endocrine System Diseases; Thyroid Diseases; Thyroiditis; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of General Surgery, Faculty of Medicine, Minia University, Minia, Egypt.

Study Record Dates

• First Submitted: June 6, 2026
• First Posted: June 17, 2026
• Study Start: February 1, 2025
• Primary Completion: February 1, 2026
• Study Completion: May 31, 2026
• Last Updated: June 17, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)