Comparison of Nerve Blocks for Pain Relief After Knee Surgery

NCT07845591 | Completed

• 1 other identifier: 2024/261
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study compares the postoperative analgesic effectiveness of ultrasound-guided fascia iliaca compartment block (FICB) with combined IPACK and genicular nerve block (GNB) in patients undergoing knee surgery under spinal anesthesia. The study includes 70 patients treated between July 2022 and July 2024. Postoperative pain scores, tramadol consumption, time to first mobilization, motor block, need for rescue analgesia, complications, and patient satisfaction are evaluated during the first 24 hours after surgery.

Conditions

Knee Surgery; Postoperative Pain

Outcome Measures

Primary Outcomes (2)

• Postoperative Pain Intensity

  Postoperative pain intensity was assessed using the Visual Analog Scale (VAS) at rest and during 45° knee flexion. VAS scores range from 0 to 10, with higher scores indicating greater pain intensity.

  At postoperative 1, 6, 12, and 24 hours

• Total Postoperative Tramadol Consumption

  Total tramadol consumption during the first 24 postoperative hours was recorded in milligrams (mg) and compared between the two study groups.

  Within the first 24 hours after surgery

Study Arms (2)

Fascia Iliaca Compartment Block Group

Procedure: Ultrasound-Guided Fascia Iliaca Compartment Block

Combined IPACK and Genicular Nerve Block Group

Procedure: Ultrasound-Guided Combined IPACK and Genicular Nerve Block

Interventions

Ultrasound-Guided Combined IPACK and Genicular Nerve Block PROCEDURE

Patients received an ultrasound-guided IPACK block combined with genicular nerve block for postoperative analgesia after knee surgery. The IPACK block was performed with 20 mL of 0.25% bupivacaine.

Combined IPACK and Genicular Nerve Block Group

Ultrasound-Guided Fascia Iliaca Compartment Block PROCEDURE

Patients received an ultrasound-guided infrainguinal fascia iliaca compartment block using 40 mL of 0.25% bupivacaine for postoperative analgesia after knee surgery.

Fascia Iliaca Compartment Block Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18-75 years with ASA physical status I-III who underwent elective knee surgery under spinal anesthesia at Gaziantep University Şahinbey Research and Training Hospital were included. Eligible patients had a BMI of 18-30 kg/m² and no contraindication to regional anesthesia. The study retrospectively evaluated patients who received either an ultrasound-guided fascia iliaca compartment block or a combined IPACK and genicular nerve block for postoperative analgesia.

You may qualify if:

• Age 18-75 years American Society of Anesthesiologists (ASA) physical status I-III Written and verbal informed consent for participation Undergoing elective knee surgery Body mass index (BMI) between 18 and 30 kg/m² No contraindication to regional anesthesia

You may not qualify if:

• Age \<18 years or \>75 years ASA physical status IV-V BMI \>30 kg/m² Allergy to local anesthetics Emergency surgery Inability to cooperate Receiving treatment for chronic pain Known neuropsychiatric disease Contraindication to neuraxial anesthesia or peripheral nerve block, including infection at the injection site, coagulation disorder, or anticoagulant use Conversion to general anesthesia before completion of surgery Severe organ failure Inaccessible medical records or refusal to participate

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

Gaziantep University

Gaziantep, 27410, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Study Record Dates

• First Submitted: September 22, 2026
• First Posted: September 29, 2026
• Study Start: July 1, 2022
• Primary Completion: July 1, 2024
• Study Completion: July 31, 2024
• Last Updated: September 29, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)