What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?

NCT07477652 | Not Yet Recruiting DMC

• 1 other identifier: AKI and Critically ill patiens
• Study Type: observational
• Target: 85
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care unit (ICU), and to identify whether AKI is an independent predictor of difficult, failed or complicated or weaning.

Conditions

AKI; Critical Illness

Outcome Measures

Primary Outcomes (1)

• Weaning success rate

  Weaning from mechanical ventilation success: defined as extubation with no need for reintubation or invasive mechanical ventilation within 48-72 hours (use the definition adopted by your ICU).

  1 year

Interventions

Acute Kidney Injury (AKI) Exposure OTHER

Participants will be categorized according to the presence or absence of Acute Kidney Injury during their ICU stay. All patients will undergo standard management of Mechanical Ventilation and routine weaning protocols as per ICU practice. The study will evaluate the association between AKI and outcomes of Weaning from Mechanical Ventilation, including success rate, duration, and complications.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critically ill patients 18 years or above with acute kidney injury.

You may qualify if:

• Age ≥ 18 years of either sex.
• Admission to the ICU and receiving invasive mechanical ventilation via endotracheal tube.
• Expected duration of mechanical ventilation ≥ 24 hours.
• Hemodynamically stable or stabilized at the time of first spontaneous breathing trial (SBT) according to unit protocol (e.g., mean arterial pressure ≥ 65 mmHg with or without low dose vasopressors).
• Availability of baseline and daily serum creatinine, urine output, and relevant clinical data to diagnose and stage acute kidney injury according to KDIGO criteria.

You may not qualify if:

• Pre existing end stage renal disease on chronic dialysis (hemodialysis or peritoneal dialysis).
• Known advanced chronic kidney disease (e.g., baseline estimated GFR \< 30 mL/min/1.73 m²) if baseline creatinine is available.
• Previous tracheostomy before current ICU admission.
• Neuromuscular diseases or spinal cord injury causing chronic ventilatory dependence.
• Severe pre existing cognitive impairment or brain death at ICU admission.
• Do not intubate or comfort care only orders at time of eligibility assessment.
• Re intubation after ICU discharge (only the first ICU admission episode will be considered).
• Patients or legal representatives refusing or withdrawing consent

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at critical care departement

Study Record Dates

• First Submitted: March 13, 2026
• First Posted: March 17, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: March 17, 2026

Record last verified: 2026-03