mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis

NCT07827443 | Not Yet Recruiting

• 1 other identifier: mFFE-MRI-KneeOA-Assiut-2026
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.

Conditions

Osteoarthritis, Knee; Bone Diseases

Keywords

mFFE MRI; Knee osteoarthritis; Cortical bone; CT-like MRI; Assiut

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of mFFE MRI for cortical bone changes

  Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard

  Baseline

Secondary Outcomes (6)

• Sensitivity of mFFE MRI for cortical bone changes

  Baseline

• Specificity of mFFE MRI for cortical bone changes

  Baseline

• Detection of subchondral sclerosis

  Baseline

• Detection of osteophytes

  Baseline

• Detection of joint space narrowing

  Baseline

Study Arms (1)

Single cohort: Patients with knee osteoarthritis

Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis attending the Diagnostic and Interventional Radiology Department at Assiut University Hospital.

You may qualify if:

• \- Age 40 years or older
• Clinically suspected or confirmed knee osteoarthritis
• Able and willing to provide informed consent

You may not qualify if:

• \- Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)
• Metallic foreign bodies in the eyes or orbits
• Ferromagnetic cerebral aneurysm clips
• Implantable infusion pumps
• Pregnancy

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Osteoarthritis, Knee; Bone Diseases

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Ehab M Mohammed, prof

  Diagnostic and interventional radiology Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Fatima M Eltony, Resident

CONTACT

+20 10 15712606; fatima.18313255@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: September 14, 2026
• First Posted: September 18, 2026
• Study Start: September 15, 2026
• Primary Completion (Estimated): September 20, 2027
• Study Completion (Estimated): February 20, 2028
• Last Updated: September 18, 2026

Record last verified: 2026-09