NCT06289218

Brief Summary

The purpose of this study will be to compare the combined effect of using Kinesio taping versus interferential current with an exercise program on knee pain, function, knee range of motion, knee muscle strength, and functional mobility in chronic knee osteoarthritis.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
63

participants targeted

Target at P50-P75 for not_applicable knee-osteoarthritis

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable knee-osteoarthritis

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 18, 2024

Completed
12 days until next milestone

First Posted

Study publicly available on registry

March 1, 2024

Completed
1.4 years until next milestone

Study Start

First participant enrolled

July 15, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 21, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 21, 2025

Completed
Last Updated

May 9, 2025

Status Verified

May 1, 2025

Enrollment Period

2 months

First QC Date

February 18, 2024

Last Update Submit

May 6, 2025

Conditions

Outcome Measures

Primary Outcomes (5)

  • knee flexion range of motion

    to measure Knee joint active range of motion (flexion) by universal goniometer

    pre-intervention and after 4 weeks of treatment

  • knee extension range of motion

    to measure Knee joint active range of motion (extension) by universal goniometer

    pre-intervention and after 4 weeks of treatment

  • quadriceps muscle strength

    to test the isometric quadriceps muscle strength by hand-held dynamometer

    pre-intervention and after 4 weeks of treatment

  • The Western Ontario and McMaster Universities Osteoarthritis Index

    to measure knee function and knee pain degree

    pre-intervention and after 4 weeks of treatment

  • Timed up and go test

    to measure knee function mobility by the Timed up and go test

    pre-intervention and after 4 weeks of treatment

Study Arms (3)

interferential current plus exercise

EXPERIMENTAL

interferential current plus exercise group

Device: interferential current

kinesio taping plus exercise

EXPERIMENTAL

kinesio taping plus exercise group

Other: kinesio taping

Control group

OTHER

Control group

Other: exercise

Interventions

IFC plus exercise

Also known as: IFC
interferential current plus exercise

KT plus exercise

Also known as: KT
kinesio taping plus exercise

exercise only

Control group

Eligibility Criteria

Age40 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • sixty-three Male and female patients aged between 40 and 65 years old were diagnosed clinically and radiologically as knee osteoarthritis grade mild and moderate chronic knee osteoarthritis.
  • BMI ranges between 20 and 32 kg/m2.
  • Knee OA grades 1 and 2 are based on Kellgren and Lawrence's grades. Narrowing of joint space, definite osteophytes.
  • Unilateral knee osteoarthritis.
  • Knee pain for most days of the prior month, in addition to at least 3 of the following:
  • Crepitus on active joint motion
  • Morning stiffness less than 30 minutes duration
  • Age older than 50 years
  • Bony enlargement of the knee on examination
  • Bony tenderness of the knee on examination
  • No palpable warmth.

You may not qualify if:

  • Patients having the following conditions will be excluded from the study:
  • Comorbidities such as (rheumatoid arthritis, cancer, osteoporosis, and joint infection).
  • Previous surgery for knee OA.
  • BMI more than 33 kg/m2.
  • Suffering from polyarticular disease.
  • Severe mechanical deformity (diaphyseal Varus deformity of 4° and valgus of 16°).
  • Previous arthroscopy within the last year.
  • Systemic autoimmune rheumatoid disease (connective tissue disease and systemic necrotizing vasculitis).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (69)

  • Aaron RK, Ciombor DM. Therapeutic effects of electromagnetic fields in the stimulation of connective tissue repair. J Cell Biochem. 1993 May;52(1):42-6. doi: 10.1002/jcb.240520107.

    PMID: 8320274BACKGROUND
  • Alqualo-Costa R, Thome GR, Perracini MR, Liebano RE. Low-level laser therapy and interferential current in patients with knee osteoarthritis: a randomized controlled trial protocol. Pain Manag. 2018 May;8(3):157-166. doi: 10.2217/pmt-2017-0057. Epub 2018 May 3.

    PMID: 29722602BACKGROUND
  • Atamaz FC, Durmaz B, Baydar M, Demircioglu OY, Iyiyapici A, Kuran B, Oncel S, Sendur OF. Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in knee osteoarthritis: a double-blind, randomized, controlled, multicenter study. Arch Phys Med Rehabil. 2012 May;93(5):748-56. doi: 10.1016/j.apmr.2011.11.037. Epub 2012 Mar 28.

    PMID: 22459699BACKGROUND
  • Aw NM, Yeo SJ, Wylde V, Wong SB, Chan D, Thumboo J, Leung YY. Impact of pain sensitisation on the quality of life of patients with knee osteoarthritis. RMD Open. 2022 Mar;8(1):e001938. doi: 10.1136/rmdopen-2021-001938.

    PMID: 35296529BACKGROUND
  • Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C. Timed Up and Go test and risk of falls in older adults: a systematic review. J Nutr Health Aging. 2011 Dec;15(10):933-8. doi: 10.1007/s12603-011-0062-0.

    PMID: 22159785BACKGROUND
  • Brunenberg DE, van Steyn MJ, Sluimer JC, Bekebrede LL, Bulstra SK, Joore MA. Joint recovery programme versus usual care: an economic evaluation of a clinical pathway for joint replacement surgery. Med Care. 2005 Oct;43(10):1018-26. doi: 10.1097/01.mlr.0000178266.75744.35.

    PMID: 16166871BACKGROUND
  • Cadogan A, Laslett M, Hing W, McNair P, Williams M. Reliability of a new hand-held dynamometer in measuring shoulder range of motion and strength. Man Ther. 2011 Feb;16(1):97-101. doi: 10.1016/j.math.2010.05.005.

    PMID: 20621547BACKGROUND
  • Celik D, Dirican A, Baltaci G. Intrarater reliability of assessing strength of the shoulder and scapular muscles. J Sport Rehabil. 2012 Feb 29;21(1):1-5. doi: 10.1123/jsr.2012.TR3. Print 2012 Feb 1.

    PMID: 22495260BACKGROUND
  • Chapple CM, Nicholson H, Baxter GD, Abbott JH. Patient characteristics that predict progression of knee osteoarthritis: a systematic review of prognostic studies. Arthritis Care Res (Hoboken). 2011 Aug;63(8):1115-25. doi: 10.1002/acr.20492.

    PMID: 21560257BACKGROUND
  • Chen HL, Yang FA, Lee TH, Liou TH, Escorpizo R, Chen HC. Effectiveness of interferential current therapy in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Sci Rep. 2022 Jun 11;12(1):9694. doi: 10.1038/s41598-022-13478-6.

    PMID: 35690604BACKGROUND
  • de Paula Gomes CAF, Politti F, de Souza Bacelar Pereira C, da Silva ACB, Dibai-Filho AV, de Oliveira AR, Biasotto-Gonzalez DA. Exercise program combined with electrophysical modalities in subjects with knee osteoarthritis: a randomised, placebo-controlled clinical trial. BMC Musculoskelet Disord. 2020 Apr 20;21(1):258. doi: 10.1186/s12891-020-03293-3.

    PMID: 32312265BACKGROUND
  • Deyle GD, Allen CS, Allison SC, Gill NW, Hando BR, Petersen EJ, Dusenberry DI, Rhon DI. Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. N Engl J Med. 2020 Apr 9;382(15):1420-1429. doi: 10.1056/NEJMoa1905877.

    PMID: 32268027BACKGROUND
  • Ellison AE, Berg EE. Embryology, anatomy, and function of the anterior cruciate ligament. Orthop Clin North Am. 1985 Jan;16(1):3-14.

    PMID: 3969275BACKGROUND
  • Escamilla RF, Zheng N, Macleod TD, Edwards WB, Hreljac A, Fleisig GS, Wilk KE, Moorman CT 3rd, Imamura R, Andrews JR. Patellofemoral joint force and stress between a short- and long-step forward lunge. J Orthop Sports Phys Ther. 2008 Nov;38(11):681-90. doi: 10.2519/jospt.2008.2694.

    PMID: 18978453BACKGROUND
  • Goats GC. Pulsed electromagnetic (short-wave) energy therapy. Br J Sports Med. 1989 Dec;23(4):213-6. doi: 10.1136/bjsm.23.4.213. No abstract available.

    PMID: 2629997BACKGROUND
  • Goats GC. Interferential current therapy. Br J Sports Med. 1990 Jun;24(2):87-92. doi: 10.1136/bjsm.24.2.87. No abstract available.

    PMID: 1702337BACKGROUND
  • Goldring MB, Goldring SR. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci. 2010 Mar;1192:230-7. doi: 10.1111/j.1749-6632.2009.05240.x.

    PMID: 20392241BACKGROUND
  • Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther. 2009;11(3):224. doi: 10.1186/ar2592. Epub 2009 May 19.

    PMID: 19519926BACKGROUND
  • Goldring SR, Goldring MB. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk. Nat Rev Rheumatol. 2016 Nov;12(11):632-644. doi: 10.1038/nrrheum.2016.148. Epub 2016 Sep 22.

    PMID: 27652499BACKGROUND
  • Gruber J, Wolter D, Lierse W. [Anterior cruciate ligament reflex (LCA reflex)]. Unfallchirurg. 1986 Dec;89(12):551-4. No abstract available. German.

    PMID: 3563529BACKGROUND
  • Guermazi M, Poiraudeau S, Yahia M, Mezganni M, Fermanian J, Habib Elleuch M, Revel M. Translation, adaptation and validation of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for an Arab population: the Sfax modified WOMAC. Osteoarthritis Cartilage. 2004 Jun;12(6):459-68. doi: 10.1016/j.joca.2004.02.006.

    PMID: 15135142BACKGROUND
  • Gunaydin OE, Bayrakci Tunay V. Comparison of the added effects of kinesio taping and extracorporeal shockwave therapy to exercise alone in knee osteoarthritis. Physiother Theory Pract. 2022 May;38(5):661-669. doi: 10.1080/09593985.2020.1780657. Epub 2020 Jun 23.

    PMID: 32574094BACKGROUND
  • Gundog M, Atamaz F, Kanyilmaz S, Kirazli Y, Celepoglu G. Interferential current therapy in patients with knee osteoarthritis: comparison of the effectiveness of different amplitude-modulated frequencies. Am J Phys Med Rehabil. 2012 Feb;91(2):107-13. doi: 10.1097/PHM.0b013e3182328687.

    PMID: 22019968BACKGROUND
  • Hamilton DF, Akhtar S, Griffiths B, Prior Y, Jones RK. The use of technology to support lifestyle interventions in knee osteoarthritis: A scoping review. Osteoarthr Cartil Open. 2023 Feb 9;5(2):100344. doi: 10.1016/j.ocarto.2023.100344. eCollection 2023 Jun.

    PMID: 36852286BACKGROUND
  • Hancock GE, Hepworth T, Wembridge K. Accuracy and reliability of knee goniometry methods. J Exp Orthop. 2018 Oct 19;5(1):46. doi: 10.1186/s40634-018-0161-5.

    PMID: 30341552BACKGROUND
  • Hirano M, Katoh M, Gomi M, Arai S. Validity and reliability of isometric knee extension muscle strength measurements using a belt-stabilized hand-held dynamometer: a comparison with the measurement using an isokinetic dynamometer in a sitting posture. J Phys Ther Sci. 2020 Feb;32(2):120-124. doi: 10.1589/jpts.32.120. Epub 2020 Feb 14.

    PMID: 32158074BACKGROUND
  • Hirschmann MT, Muller W. Complex function of the knee joint: the current understanding of the knee. Knee Surg Sports Traumatol Arthrosc. 2015 Oct;23(10):2780-8. doi: 10.1007/s00167-015-3619-3. Epub 2015 May 12.

    PMID: 25962963BACKGROUND
  • Johansson H, Sjolander P, Sojka P. A sensory role for the cruciate ligaments. Clin Orthop Relat Res. 1991 Jul;(268):161-78.

    PMID: 2060205BACKGROUND
  • Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021 Feb 9;325(6):568-578. doi: 10.1001/jama.2020.22171.

    PMID: 33560326BACKGROUND
  • Lee R, Kean WF. Obesity and knee osteoarthritis. Inflammopharmacology. 2012 Apr;20(2):53-8. doi: 10.1007/s10787-011-0118-0. Epub 2012 Jan 12.

    PMID: 22237485BACKGROUND
  • Lehman GJ, Hoda W, Oliver S. Trunk muscle activity during bridging exercises on and off a Swiss ball. Chiropr Osteopat. 2005 Jul 30;13:14. doi: 10.1186/1746-1340-13-14.

    PMID: 16053529BACKGROUND
  • Lenssen AF, van Dam EM, Crijns YH, Verhey M, Geesink RJ, van den Brandt PA, de Bie RA. Reproducibility of goniometric measurement of the knee in the in-hospital phase following total knee arthroplasty. BMC Musculoskelet Disord. 2007 Aug 17;8:83. doi: 10.1186/1471-2474-8-83.

    PMID: 17705860BACKGROUND
  • Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee Osteoarthritis: A Primer. Perm J. 2017;21:16-183. doi: 10.7812/TPP/16-183.

    PMID: 29035179BACKGROUND
  • Lin CH, Lee M, Lu KY, Chang CH, Huang SS, Chen CM. Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2020 Aug;34(8):1014-1027. doi: 10.1177/0269215520928398. Epub 2020 Jun 28.

    PMID: 32597199BACKGROUND
  • Lu Z, Li X, Chen R, Guo C. Kinesio taping improves pain and function in patients with knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2018 Nov;59:27-35. doi: 10.1016/j.ijsu.2018.09.015. Epub 2018 Sep 28.

    PMID: 30273684BACKGROUND
  • Mansfield JC, Winlove CP. A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage. J Anat. 2012 Apr;220(4):405-16. doi: 10.1111/j.1469-7580.2012.01479.x. Epub 2012 Feb 14.

    PMID: 22332832BACKGROUND
  • Mao HY, Hu MT, Yen YY, Lan SJ, Lee SD. Kinesio Taping Relieves Pain and Improves Isokinetic Not Isometric Muscle Strength in Patients with Knee Osteoarthritis-A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021 Oct 4;18(19):10440. doi: 10.3390/ijerph181910440.

    PMID: 34639740BACKGROUND
  • McCloskey DI, Cross MJ, Honner R, Potter EK. Sensory effects of pulling or vibrating exposed tendons in man. Brain. 1983 Mar;106 (Pt 1):21-37. doi: 10.1093/brain/106.1.21.

    PMID: 6831197BACKGROUND
  • McConnell S, Kolopack P, Davis AM. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): a review of its utility and measurement properties. Arthritis Rheum. 2001 Oct;45(5):453-61. doi: 10.1002/1529-0131(200110)45:53.0.co;2-w. No abstract available.

    PMID: 11642645BACKGROUND
  • Mitra, M., & Gaikwad, N. (2019). The Effect of Straight Leg Raise with Lumbar Stabilization Exercises in Subjects of Low Back Pain with Adverse Neural Tension between the Age Group 20-50 Years. Executive Editor, 13(1), 101.

    BACKGROUND
  • Mohamed SHP, Alatawi SF. Effectiveness of Kinesio taping and conventional physical therapy in the management of knee osteoarthritis: a randomized clinical trial. Ir J Med Sci. 2023 Oct;192(5):2223-2233. doi: 10.1007/s11845-022-03247-9. Epub 2022 Dec 17.

    PMID: 36527538BACKGROUND
  • Morris S, Morris ME, Iansek R. Reliability of measurements obtained with the Timed "Up & Go" test in people with Parkinson disease. Phys Ther. 2001 Feb;81(2):810-8. doi: 10.1093/ptj/81.2.810.

    PMID: 11175678BACKGROUND
  • Musumeci, G. (2016). The effect of mechanical loading on articular cartilage. Journal of Functional Morphology and Kinesiology, 1(2), 154-161.

    BACKGROUND
  • Kaya Mutlu E, Mustafaoglu R, Birinci T, Razak Ozdincler A. Does Kinesio Taping of the Knee Improve Pain and Functionality in Patients with Knee Osteoarthritis?: A Randomized Controlled Clinical Trial. Am J Phys Med Rehabil. 2017 Jan;96(1):25-33. doi: 10.1097/PHM.0000000000000520.

    PMID: 27149590BACKGROUND
  • Parreira Pdo C, Costa Lda C, Hespanhol LC Jr, Lopes AD, Costa LO. Current evidence does not support the use of Kinesio Taping in clinical practice: a systematic review. J Physiother. 2014 Mar;60(1):31-9. doi: 10.1016/j.jphys.2013.12.008. Epub 2014 Apr 24.

    PMID: 24856938BACKGROUND
  • Paul-Dauphin A, Guillemin F, Virion JM, Briancon S. Bias and precision in visual analogue scales: a randomized controlled trial. Am J Epidemiol. 1999 Nov 15;150(10):1117-27. doi: 10.1093/oxfordjournals.aje.a009937.

    PMID: 10568628BACKGROUND
  • Pinto-Ramos J, Moreira T, Costa F, Tavares H, Cabral J, Costa-Santos C, Barroso J, Sousa-Pinto B. Handheld dynamometer reliability to measure knee extension strength in rehabilitation patients-A cross-sectional study. PLoS One. 2022 May 17;17(5):e0268254. doi: 10.1371/journal.pone.0268254. eCollection 2022.

    PMID: 35580110BACKGROUND
  • Prathap Kumar, J., Arun Kumar, M., & Venkatesh, D. (2020). Healthy gait: Review of anatomy and physiology of knee joint. International Journal of Current Research and Review, 12(6), 1-8.

    BACKGROUND
  • Prentice AM, Jebb SA. Beyond body mass index. Obes Rev. 2001 Aug;2(3):141-7. doi: 10.1046/j.1467-789x.2001.00031.x.

    PMID: 12120099BACKGROUND
  • Primorac D, Molnar V, Rod E, Jelec Z, Cukelj F, Matisic V, Vrdoljak T, Hudetz D, Hajsok H, Boric I. Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations. Genes (Basel). 2020 Jul 26;11(8):854. doi: 10.3390/genes11080854.

    PMID: 32722615BACKGROUND
  • Rampazo EP, Liebano RE. Analgesic Effects of Interferential Current Therapy: A Narrative Review. Medicina (Kaunas). 2022 Jan 17;58(1):141. doi: 10.3390/medicina58010141.

    PMID: 35056448BACKGROUND
  • Raposo F, Ramos M, Lucia Cruz A. Effects of exercise on knee osteoarthritis: A systematic review. Musculoskeletal Care. 2021 Dec;19(4):399-435. doi: 10.1002/msc.1538. Epub 2021 Mar 5.

    PMID: 33666347BACKGROUND
  • Reginster, J. Y., Pelletier, J. P., Martel-Pelletier, J., Henrotin, Y., Crasborn, L., Crielaard, J. M., & Henrotin, Y. (1999). Scientific basis of physical therapy and rehabilitation in the management of patients with osteoarthritis. Osteoarthritis: Clinical and Experimental Aspects, 453-479.

    BACKGROUND
  • Rogind H, Bibow-Nielsen B, Jensen B, Moller HC, Frimodt-Moller H, Bliddal H. The effects of a physical training program on patients with osteoarthritis of the knees. Arch Phys Med Rehabil. 1998 Nov;79(11):1421-7. doi: 10.1016/s0003-9993(98)90238-6.

    PMID: 9821904BACKGROUND
  • Ruhlen R, Marberry K. The chondrocyte primary cilium. Osteoarthritis Cartilage. 2014 Aug;22(8):1071-6. doi: 10.1016/j.joca.2014.05.011. Epub 2014 May 29.

    PMID: 24879961BACKGROUND
  • Sanchez M, Fiz N, Azofra J, Usabiaga J, Aduriz Recalde E, Garcia Gutierrez A, Albillos J, Garate R, Aguirre JJ, Padilla S, Orive G, Anitua E. A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis. Arthroscopy. 2012 Aug;28(8):1070-8. doi: 10.1016/j.arthro.2012.05.011.

    PMID: 22840987BACKGROUND
  • Shamsi M, Mirzaei M, Khabiri SS. Universal goniometer and electro-goniometer intra-examiner reliability in measuring the knee range of motion during active knee extension test in patients with chronic low back pain with short hamstring muscle. BMC Sports Sci Med Rehabil. 2019 Mar 22;11:4. doi: 10.1186/s13102-019-0116-x. eCollection 2019.

    PMID: 30949343BACKGROUND
  • Suzuki K, Akasaka K, Otsudo T, Sawada Y, Hattori H, Hasebe Y, Mizoguchi Y, Hall TM, Yamamoto M. Effects of functional movement screen training in high-school baseball players: A randomized controlled clinical trial. Medicine (Baltimore). 2021 Apr 9;100(14):e25423. doi: 10.1097/MD.0000000000025423.

    PMID: 33832142BACKGROUND
  • Tsokanos A, Livieratou E, Billis E, Tsekoura M, Tatsios P, Tsepis E, Fousekis K. The Efficacy of Manual Therapy in Patients with Knee Osteoarthritis: A Systematic Review. Medicina (Kaunas). 2021 Jul 7;57(7):696. doi: 10.3390/medicina57070696.

    PMID: 34356977BACKGROUND
  • Tsuda E, Okamura Y, Otsuka H, Komatsu T, Tokuya S. Direct evidence of the anterior cruciate ligament-hamstring reflex arc in humans. Am J Sports Med. 2001 Jan-Feb;29(1):83-7. doi: 10.1177/03635465010290011801.

    PMID: 11206261BACKGROUND
  • Turner MN, Hernandez DO, Cade W, Emerson CP, Reynolds JM, Best TM. The Role of Resistance Training Dosing on Pain and Physical Function in Individuals With Knee Osteoarthritis: A Systematic Review. Sports Health. 2020 Mar/Apr;12(2):200-206. doi: 10.1177/1941738119887183. Epub 2019 Dec 18.

    PMID: 31850826BACKGROUND
  • Watkins MA, Riddle DL, Lamb RL, Personius WJ. Reliability of goniometric measurements and visual estimates of knee range of motion obtained in a clinical setting. Phys Ther. 1991 Feb;71(2):90-6; discussion 96-7. doi: 10.1093/ptj/71.2.90.

    PMID: 1989012BACKGROUND
  • Wikholm JB, Bohannon RW. Hand-held Dynamometer Measurements: Tester Strength Makes a Difference. J Orthop Sports Phys Ther. 1991;13(4):191-8. doi: 10.2519/jospt.1991.13.4.191.

    PMID: 18796845BACKGROUND
  • Wodowski AJ, Swigler CW, Liu H, Nord KM, Toy PC, Mihalko WM. Proprioception and Knee Arthroplasty: A Literature Review. Orthop Clin North Am. 2016 Apr;47(2):301-9. doi: 10.1016/j.ocl.2015.09.005.

    PMID: 26772938BACKGROUND
  • Wu JP, Kirk TB, Zheng MH. Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique. J Orthop Surg Res. 2008 Jul 17;3:29. doi: 10.1186/1749-799X-3-29.

    PMID: 18637164BACKGROUND
  • Xia B, Di Chen, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int. 2014 Dec;95(6):495-505. doi: 10.1007/s00223-014-9917-9. Epub 2014 Oct 14.

    PMID: 25311420BACKGROUND
  • Zampieri S, Mosole S, Lofler S, Fruhmann H, Burggraf S, Cvecka J, Hamar D, Sedliak M, Tirptakova V, Sarabon N, Mayr W, Kern H. Physical Exercise in Aging: Nine Weeks of Leg Press or Electrical Stimulation Training in 70 Years Old Sedentary Elderly People. Eur J Transl Myol. 2015 Aug 25;25(4):237-42. doi: 10.4081/ejtm.2015.5374. eCollection 2015 Aug 24.

    PMID: 26913162BACKGROUND
  • Zeng C, Li H, Yang T, Deng ZH, Yang Y, Zhang Y, Lei GH. Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis. Osteoarthritis Cartilage. 2015 Feb;23(2):189-202. doi: 10.1016/j.joca.2014.11.014. Epub 2014 Nov 26.

    PMID: 25497083BACKGROUND
  • Lun V, Marsh A, Bray R, Lindsay D, Wiley P. Efficacy of Hip Strengthening Exercises Compared With Leg Strengthening Exercises on Knee Pain, Function, and Quality of Life in Patients With Knee Osteoarthritis. Clin J Sport Med. 2015 Nov;25(6):509-17. doi: 10.1097/JSM.0000000000000170.

    PMID: 25591130BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Electric Stimulation TherapyExercise

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Intervention Hierarchy (Ancestors)

TherapeuticsPhysical Therapy ModalitiesRehabilitationMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Salwa Fadl Abd Elmageed, Prof.Dr

    Professor at Department of Physical Therapy for Musculoskeletal Disorders and Its Surgery

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Nourhan Elsaid Ahmed Elsaid

CONTACT

Marihan Zakaria Aziz Makary, Dr

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

February 18, 2024

First Posted

March 1, 2024

Study Start

July 15, 2025

Primary Completion

September 21, 2025

Study Completion

September 21, 2025

Last Updated

May 9, 2025

Record last verified: 2025-05