Prognostic Value of Pulse Oximetry Differences

NCT07824414 | Recruiting

• 2 other identifiers: 4-2025-14896-2025-0076
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate whether the difference between finger, earlobe and forehead SpO₂ (ΔSpO₂) measured at emergency department (ED) presentation is associated with clinical outcomes in adult patients presenting with dyspnea. We will compare ΔSpO₂ between patients with poor outcomes (death or intensive care unit \[ICU\] admission) and those with favorable outcomes. Secondary objectives include assessing the prognostic value of ΔSpO₂ for mortality, ICU admission, and lactate, and comparing its predictive performance with established early warning scores.

Conditions

Dyspnea

Outcome Measures

Primary Outcomes (1)

• In-hospital mortality or ICU admission

  In-hospital mortality or ICU admission of index visit

  From the index emergency department visit through hospital discharge, assessed up to 6 months.

Study Arms (1)

Dyspnea cohort

Patients visiting emergency department with dyspnea who are categorized to KTAS 1-3

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will enroll patients who meet the enrollment criteria who visit an emergency department of a tertiary teaching hospital located in Seoul, South Korea.

You may qualify if:

• Adult patients aged 19 years or older presenting to the emergency department with dyspnea, classified as KTAS level 1-3

You may not qualify if:

• Patients in whom SpO₂ measurements were not obtained simultaneously
• Patients in whom arterial blood gas analysis was not ordered at initial evaluation
• Pregnant patients
• Patients with facial trauma or hand trauma
• Patients with amputation, injury, or burns at the measurement sites
• Patients wearing nail polish
• Patients with dyshemoglobinemia
• Non-Korean nationality
• Patients who did not provide consent to participate in the study

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Yonsei University Severance Hospital

Seoul, Seoul, 03722, South Korea

RECRUITING

MeSH Terms

Conditions

Dyspnea

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Stephen GW LEE, MD

CONTACT

82-10-5124-8415; leestephengyungwon@yuhs.ac

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical assistant professor

Study Record Dates

• First Submitted: May 30, 2026
• First Posted: September 17, 2026
• Study Start: May 29, 2026
• Primary Completion (Estimated): March 31, 2027
• Study Completion (Estimated): April 30, 2027
• Last Updated: September 17, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)