Renal Doppler Indices for Predicting Acute Kidney Injury After Isolated CABG

NCT07821983 | Not Yet Recruiting

• 1 other identifier: 2024-TBEK 2026/09-20
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury can occur after coronary artery bypass grafting (CABG). This prospective, single-center observational study will evaluate whether two measurements obtained from renal Doppler ultrasound-the renal augmented velocity index (AVI) and renal resistive index (RRI)-can help predict postoperative acute kidney injury. About 200 adults undergoing elective isolated CABG with cardiopulmonary bypass will have bilateral renal Doppler examinations one day before surgery, within 60 minutes after admission to the intensive care unit, and 6 hours after intensive care unit admission. The primary outcome is acute kidney injury within the first 7 days after surgery, defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Ultrasound measurements will be analyzed offline and will not influence clinical care.

Conditions

Coronary Artery Disease; Acute Kidney Injury

Keywords

renal augmented velocity index; renal resistive index; renal Doppler ultrasonography; acute kidney injury; coronary artery bypass grafting; cardiac surgery; KDIGO; prognostic biomarker

Outcome Measures

Primary Outcomes (1)

• Incidence of Acute Kidney Injury According to KDIGO Criteria

  Number and percentage of participants who develop acute kidney injury according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria, based on serum creatinine and/or urine output.

  From surgery through postoperative day 7

Secondary Outcomes (9)

• Incidence of KDIGO Stage 2 or 3 Acute Kidney Injury

  From surgery through postoperative day 7

• Need for Renal Replacement Therapy

  During the index hospitalization, up to 30 days after surgery

• Duration of Mechanical Ventilation

  During the index hospitalization, up to 30 days after surgery

• Intensive Care Unit Length of Stay

  During the index hospitalization, up to 30 days after surgery

• Hospital Length of Stay

  During the index hospitalization, up to 30 days after surgery

Study Arms (1)

Elective Isolated On-Pump CABG Cohort

Adults scheduled for elective isolated coronary artery bypass grafting with cardiopulmonary bypass. Bilateral renal Doppler ultrasonography is performed one day before surgery and at 0 and 6 hours after ICU admission. Renal augmented velocity index and renal resistive index measurements are analyzed offline and are not used to guide clinical care.

Diagnostic Test: Renal Doppler Ultrasonography

Interventions

Renal Doppler Ultrasonography DIAGNOSTIC_TEST

Bilateral renal Doppler examinations are performed at T0 (one day before surgery after at least 10 minutes of rest), T1 (within the first 60 minutes after postoperative ICU admission), and T2 (6 hours after ICU admission). Renal augmented velocity index and renal resistive index are calculated offline from stored waveforms. Study measurements do not guide clinical care.

Also known as: Renal Doppler Ultrasound

Elective Isolated On-Pump CABG Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults scheduled for elective isolated on-pump coronary artery bypass grafting at Bursa Yuksek Ihtisas Training and Research Hospital who meet all eligibility criteria. Consecutive eligible patients will be approached before surgery.

You may qualify if:

• Age 18 years or older.
• Scheduled for elective isolated coronary artery bypass grafting with cardiopulmonary bypass (on-pump).
• Able and willing to provide written informed consent.
• Both kidneys present.
• Adequate bilateral preoperative renal Doppler signal for study measurements.

You may not qualify if:

• Preoperative chronic dialysis or renal replacement therapy.
• Urgent or emergency surgery.
• Combined cardiac surgery, including valve, aortic, or another major additional procedure.
• Off-pump coronary artery bypass grafting or conversion of the planned surgical technique.
• Clinically significant rhythm disturbance preventing acquisition of three interpretable cardiac cycles.
• Renal transplant, solitary kidney, significant renal artery stenosis, previous renal artery intervention, hydronephrosis, or other relevant renal vascular or structural disease.
• Inadequate bilateral preoperative renal Doppler examination.
• Withdrawal of consent.

Sponsors & Collaborators

• Bursa Yuksek Ihtisas Training and Research Hospital: lead

Study Sites (1)

Bursa Yuksek Ihtisas Training and Research Hospital

Bursa, Bursa, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Acute Kidney Injury; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Nuri Burkay Soylu, MD

  Bursa Yuksek Ihtisas Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nuri Burkay Soylu, MD

CONTACT

+90 538 248 4728; drburkaysoylu@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Specialist Physician

Study Record Dates

• First Submitted: September 10, 2026
• First Posted: September 16, 2026
• Study Start: September 15, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: September 16, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)