MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG

NCT07823400 | Recruiting

• 1 other identifier: 2024-TBEK 2026/01-10
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study evaluates the effects of minimally invasive extracorporeal circulation (MIECC) and conventional cardiopulmonary bypass on systemic inflammatory response in patients undergoing coronary artery bypass graft surgery. Adult patients undergoing elective coronary artery bypass surgery will be observed according to the extracorporeal circulation technique used during surgery. Systemic inflammation will be assessed using routinely available hematologic inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). These parameters will be evaluated preoperatively, at postoperative 6 hours, at postoperative 24 hours, and at hospital discharge. The study will also evaluate selected perioperative and postoperative clinical outcomes in order to compare the inflammatory response associated with MIECC and conventional extracorporeal circulation.

Conditions

Coronary Artery Disease; Systemic Inflammation

Keywords

Minimally Invasive Extracorporeal Circulation; MIECC; Cardiopulmonary Bypass; Systemic Inflammation; Neutrophil-to-Lymphocyte Ratio; Platelet-to-Lymphocyte Ratio; Systemic Immune-Inflammation Index; Coronary Artery Bypass Grafting

Outcome Measures

Primary Outcomes (3)

• Neutrophil-to-Lymphocyte Ratio (NLR)

  NLR will be calculated from routine complete blood count values by dividing the absolute neutrophil count by the absolute lymphocyte count. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.

  Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.

• Platelet-to-Lymphocyte Ratio (PLR)

  PLR will be calculated from routine complete blood count values by dividing the platelet count by the absolute lymphocyte count. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.

  Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.

• Systemic Immune-Inflammation Index (SII)

  SII will be calculated as neutrophil count × platelet count / lymphocyte count using routine complete blood count values. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.

  Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.

Study Arms (2)

MIECC Group

Patients undergoing coronary artery bypass graft surgery using minimally invasive extracorporeal circulation (MIECC) as part of routine clinical care.

Procedure: Minimally Invasive Extracorporeal Circulation

Conventional Cardiopulmonary Bypass Group

Patients undergoing coronary artery bypass graft surgery using conventional cardiopulmonary bypass as part of routine clinical care.

Procedure: Conventional Cardiopulmonary Bypass

Interventions

Minimally Invasive Extracorporeal Circulation PROCEDURE

Use of a minimally invasive extracorporeal circulation system during coronary artery bypass graft surgery as part of routine clinical care.

MIECC Group

Conventional Cardiopulmonary Bypass PROCEDURE

Use of conventional cardiopulmonary bypass during coronary artery bypass graft surgery as part of routine clinical care.

Conventional Cardiopulmonary Bypass Group

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 30-70 years undergoing elective coronary artery bypass graft surgery with either minimally invasive extracorporeal circulation or conventional cardiopulmonary bypass at Bursa Yuksek Ihtisas Training and Research Hospital.

You may qualify if:

• Age 30-70 years
• Patients undergoing elective coronary artery bypass graft surgery
• Patients in whom cardiopulmonary bypass is planned
• Written informed consent obtained

You may not qualify if:

• Emergency surgery
• Redo cardiac surgery
• Concomitant valve surgery
• Previous open heart surgery
• Preoperative renal and/or hepatic failure
• Malignancy
• Active infection or inflammatory disease-

Sponsors & Collaborators

• Bursa Yuksek Ihtisas Training and Research Hospital: lead

Study Sites (1)

Bursa Yuksek Ihtisas Training and Research Hospital

Bursa, Bursa, 16000, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Central Study Contacts

Ümran Karaca, M.D.

CONTACT

+90 505 494 16 87; umransuna@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: September 10, 2026
• First Posted: September 16, 2026
• Study Start: February 7, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: September 16, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)