CPB and Aortic Cross-Clamp Durations and ICU Length of Stay After CABG Retrospective Observational Cohort Study

NCT07711951 | Recruiting

• 1 other identifier: 05.06.2026-276
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiopulmonary bypass (CPB) and aortic cross-clamp (ACC) durations are important intraoperative factors that may influence postoperative recovery following coronary artery bypass graft (CABG) surgery. Prolonged CPB and ACC durations may be associated with increased postoperative morbidity and extended intensive care unit (ICU) stay. This retrospective observational cohort study aims to evaluate the independent associations of CPB and ACC durations with postoperative ICU length of stay in adult patients undergoing elective isolated CABG surgery. Electronic medical records of eligible patients who underwent surgery between January 1, 2019, and December 31, 2025, at a single tertiary care center will be retrospectively reviewed. Multivariable regression analyses will be performed to assess these associations after adjustment for clinically relevant potential confounders.

Conditions

Coronary Artery Disease

Keywords

Cardiac Surgery

Outcome Measures

Primary Outcomes (1)

• Postoperative Intensive Care Unit Length of Stay

  Postoperative intensive care unit length of stay will be defined as the duration from admission to the intensive care unit following surgery until transfer from the intensive care unit to the hospital ward and will be recorded in days. Patients who die during the intensive care unit stay will not be included in the primary intensive care unit length-of-stay analysis.

  Up to 30 days after surgery

Secondary Outcomes (4)

• Postoperative Atrial Fibrillation

  Up to 30 days after surgery

• Acute Kidney Injury

  Up to 30 days after surgery

• Postoperative Respiratory Failure

  Up to 30 days after surgery

• 30-Day All-Cause Mortality

  Within 30 days after surgery

Study Arms (1)

Elective Isolated CABG Cohort

Adult patients who underwent elective isolated coronary artery bypass graft surgery between January 1, 2019, and December 31, 2025, and met the predefined eligibility criteria. Cardiopulmonary bypass and aortic cross-clamp durations will be evaluated as continuous exposure variables.

Other: Cardiopulmonary Bypass Duration; Other: Aortic Cross-Clamp Duration

Interventions

Aortic Cross-Clamp Duration OTHER

Aortic cross-clamp duration, defined as the total duration of aortic cross-clamping during elective isolated coronary artery bypass graft surgery and recorded in minutes. This exposure will be evaluated as a continuous variable based on routinely collected operative and perfusion records.

Elective Isolated CABG Cohort

Cardiopulmonary Bypass Duration OTHER

Cardiopulmonary bypass duration, defined as the total duration of cardiopulmonary bypass during elective isolated coronary artery bypass graft surgery and recorded in minutes. This exposure will be evaluated as a continuous variable based on routinely collected perfusion records.

Elective Isolated CABG Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who underwent elective isolated coronary artery bypass graft surgery at a single tertiary care center between January 1, 2019, and December 31, 2025. All patients meeting the predefined eligibility criteria and with complete electronic medical records required for the study analyses will be included in the retrospective cohort.

You may qualify if:

• Age 18 years or older
• Underwent elective isolated coronary artery bypass graft surgery
• Surgery performed between January 1, 2019, and December 31, 2025
• Availability of complete electronic medical records required for the study analyses

You may not qualify if:

• Emergency coronary artery bypass graft surgery
• Concomitant valve surgery
• Concomitant aortic surgery
• Reoperation cases
• Incomplete study-related data
• Intraoperative death

Sponsors & Collaborators

• Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital: lead

Study Sites (1)

Fatma Acil

Diyarbakır, Outside of the US, 21070, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Anastasiadis K, Antonitsis P, Voucharas C, Apostolidou-Kiouti F, Deliopoulos A, Haidich AB, Argiriadou H. Minimal invasive extracorporeal circulation versus conventional cardiopulmonary bypass in cardiac surgery: a contemporary systematic review and meta-analysis. Eur J Cardiothorac Surg. 2025 Mar 28;67(4):ezaf112. doi: 10.1093/ejcts/ezaf112.

  PMID: 40131383 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Fatma Acil, M.D.

  Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fatma Acil, M.D.

CONTACT

+905337225225; acilfatma@gmail.com

Andaç Dedeoğlu, M.D.

CONTACT

+905326848626; anderen77@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 14, 2026
• First Posted: July 17, 2026
• Study Start: July 20, 2026
• Primary Completion (Estimated): August 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: July 21, 2026

Record last verified: 2026-07

Locations

TU (1)