RDRI and NGAL in Acute Kidney Injury in Abdominal Surgery

NCT05929573 | Completed

• 1 other identifier: Ercan01
• Study Type: observational
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury (AKI), which can occur after major surgeries, leads to increased morbidity and mortality if not detected and managed promptly. In clinical practice, serum creatinine and urine output values of patients are monitored to detect AKI, but these parameters can cause delays in diagnosis. Additionally, studies have been conducted on biomarkers such as Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C in recent years, but definitive results have not been achieved. Renal Doppler Resistive Index (RDRI) is a non-invasive index believed to reflect renal vascular perfusion. RDRI measurement is a repeatable, inexpensive, and easy-to-apply technique. RDRI has been found to be associated with AKI in conditions such as renal dysfunction, hypertension, and post-traumatic hemorrhagic shock. Furthermore, due to the impact on renal perfusion in patients undergoing major surgery, RDRI, which reflects renal vascular resistance, can serve as an indicator of kidney perfusion. The aim of this study is to test the hypothesis, 'Does measuring postoperative RDRI in major abdominal surgery cases yield higher sensitivity and specificity values in detecting acute kidney injury compared to NGAL?'

Conditions

Acute Kidney Injury

Keywords

Acute kidney injury; Neutrophil Gelatinase-Associated Lipocalin; Renal Doppler Resistive Index; Major Abdominal Surgery

Outcome Measures

Primary Outcomes (2)

• Plasma NGAL Level

  From patients undergoing major abdominal surgery, a blood sample will be taken at Postop 4th Hour for serum NGAL analysis

  Postoperative 4th hour

• Renal Doppler Resistive Index

  Renal Doppler Resistive Index will be measured at the 4th hour after major abdominal surgery.

  Postoperative 4th hour

Interventions

Neutrophil Gelatinase-Associated Lipocalin DIAGNOSTIC_TEST

Neutrophil Gelatinase-Associated Lipocalin, which can be measured from serum or urine, can detect acute kidney failure that may occur after surgery in the early stages.

Renal Doppler Resistive Index DIAGNOSTIC_TEST

Renal Doppler Resistive Index (RDRI) is a non-invasive index believed to reflect renal vascular perfusion. RDRI measurement is a repeatable, inexpensive, and easy-to-apply technique. RDRI has been found to be associated with AKI in conditions such as renal dysfunction, hypertension, and post-traumatic hemorrhagic shock. Furthermore, due to the impact on renal perfusion in patients undergoing major surgery, RDRI, which reflects renal vascular resistance, can serve as an indicator of kidney perfusion.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who will undergo major abdominal surgery in Antalya Training and Research Hospital.

You may qualify if:

• ASA I-III,
• Patients undergoing elective major abdominal surgery

You may not qualify if:

• Chronic kidney failure,
• Using nephrotoxic drugs,
• Patients with a history of kidney transplantation or nephrectomy

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

Study Sites (1)

Antalya Training and Research Hospital

Antalya, Turkey (Türkiye)

Location

Related Publications (2)

• Zeng X, McMahon GM, Brunelli SM, Bates DW, Waikar SS. Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol. 2014 Jan;9(1):12-20. doi: 10.2215/CJN.02730313. Epub 2013 Oct 31.

  PMID: 24178971 BACKGROUND

• Muthukrishnan K, Parida S, Barathi SD, Badhe AS, Mishra SK. Doppler resistive index to reflect risk of acute kidney injury after major abdominal surgery: A prospective observational trial. Indian J Anaesth. 2019 Jul;63(7):551-557. doi: 10.4103/ija.IJA_189_19.

  PMID: 31391618 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Erhan OZYURT, Assoc. Prof.

  Antalya Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, M.D.

Study Record Dates

• First Submitted: June 25, 2023
• First Posted: July 3, 2023
• Study Start: July 1, 2023
• Primary Completion: December 31, 2023
• Study Completion: July 20, 2024
• Last Updated: July 30, 2024

Record last verified: 2024-07

Locations

TU (1)