The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU Trial

NCT07820319 | Recruiting

• 1 other identifier: UW 26-246
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates a new single-beat echocardiographic technique (TE-e', the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging) for estimating left atrial pressure (LAP) in critically ill patients, comparing it against the standard two-beat method. The goal is to determine whether the faster, single-beat method gives results as reliable as the conventional method, and whether it can help identify patients with elevated left atrial pressure without an invasive procedure.

Conditions

Echocardiography; Critical Illness; Elevated Left Atrial Pressure; Left Ventricular Diastolic Dysfunction

Keywords

critical care echocardiography; transthoracic echocardiography; left atrial pressure; diastolic dysfunction; critically ill; echocardiography; tissue doppler imaging; intensive care; TE-e'

Outcome Measures

Primary Outcomes (1)

• Correlation between novel (single-beat) and conventional (two-beat) TE-e' values

  At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)

Secondary Outcomes (3)

• Correlation between novel and conventional methods in obtaining septal e' and s' velocities - At time of index TTE

  At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)

• Correlation between clinical evaluation of LAP and TE-e' value

  At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)

• Correlation between other echocardiographic parameters of LAP (E/A ratio, LAVi, TR Vmax, lung ultrasound 6-point protocol) and TE-e' value

  At the time of index TTE (single time point for each patient) during the course of ICU stay (from day 1 of ICU admission till ICU discharge, up to 1 month)

Study Arms (1)

Single cohort

each patient serves as their own comparison - conventional vs. novel method measured within the same transthoracic echocardiography study

Diagnostic Test: Echocardiography

Interventions

Echocardiography DIAGNOSTIC_TEST

Full echocardiogram performed on recruited patients.

Single cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to Adult Intensive Care Unit requiring a TTE

You may qualify if:

• Adult patients ≥18 years admitted to the QMH Adult Intensive Care Unit (AICU)
• Requiring a transthoracic echocardiogram (TTE) as part of routine clinical care
• TE-e' obtainable by both the conventional and the novel method

You may not qualify if:

• Patients \<18 years of age
• Patients in atrial fibrillation
• Patients with a poor TTE acoustic window
• Patients in whom TE-e' is technically difficult to obtain or interpret by either method

Sponsors & Collaborators

• Queen Mary Hospital, Hong Kong: lead

Study Sites (1)

Adult Intensive Care Unit, Queen Mary Hospital

Hong Kong, Hong Kong

RECRUITING

MeSH Terms

Conditions

Critical Illness; Ventricular Dysfunction, Left

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Ventricular Dysfunction; Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Central Study Contacts

Wincy Ng, MBBS

CONTACT

22551331; wincyngwingsze@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Consultant

Study Record Dates

• First Submitted: September 1, 2026
• First Posted: September 15, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 30, 2027
• Last Updated: September 15, 2026

Record last verified: 2026-09

Locations

HK (1)