NCT07810049

Brief Summary

Investigate feasibility of synchronous bilateral talc pleurodesis for malignant bilateral pleural effusions

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
31

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 1998

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1998

Completed
27.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

January 15, 2026

Completed
8 months until next milestone

First Posted

Study publicly available on registry

September 9, 2026

Completed
Last Updated

September 9, 2026

Status Verified

January 1, 2026

Enrollment Period

27.8 years

First QC Date

January 15, 2026

Last Update Submit

September 8, 2026

Conditions

Bilateral Pleural EffusionPleurodesis

Keywords

lung cancermalignant pleural effusionpleurodesisbilateral pleural effusion

Outcome Measures

Primary Outcomes (2)

  • postoperative mortality

    Evaluation of postoperative complications occurred after talc pleurodesis.

    35 years

  • postoperative morbidity

    Evaluation of postoperative complications occurred after talc pleurodesis.

    35 years

Study Arms (1)

Patient diagnosed of malignant bilateral pleural effusions

Patient diagnosed of malignant bilateral pleural effusions that underwent a synchronous bilateral talc pleurodesis

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patient diagnosed with malignant pleural bilateral effusion

You may qualify if:

  • Age ≥ 18 year-old
  • Patients undergoing synchronous bilateral talc pleurodesis
  • Diagnosis of malignant bilateral pleural effusions
  • Surgical resection between 1998 and September 2025

You may not qualify if:

  • Other type of surgery
  • Lack of consent to research
  • Other type of diagnosis (e.g. viral disease)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Istituto Europeo di Oncologia

Milan, Italy

Location

MeSH Terms

Conditions

Lung NeoplasmsPleural Effusion, Malignant

Condition Hierarchy (Ancestors)

Respiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseasesPleural NeoplasmsPleural EffusionPleural Diseases

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 15, 2026

First Posted

September 9, 2026

Study Start

January 1, 1998

Primary Completion

September 30, 2025

Study Completion

September 30, 2025

Last Updated

September 9, 2026

Record last verified: 2026-01

Locations

IT(1)