Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound

NCT07147270 | Recruiting DMC

• 1 other identifier: FMASU R107/2025
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

chemical pleurodesis using doxycycline is an acceptable and commonly employed palliation for malignant pleural effusion. Rotation of patient during pleurodesis using the powder from doxycycline capsule is still practiced in some centers. The benefit of rotation practice in pleurodesis can be verified after properly designed study on the outcome of pleurodesis with rotation and non-rotation by chest ultrasound assessment

Conditions

Effect of Patient Rotation on Pleurodesis Success and Patient Comfort; Malignant Pleural Effusion; Pleurodesis

Outcome Measures

Primary Outcomes (1)

• Measurement of pleural adhesion score in patients with malignant pleural effusion candidates for pleurodesis in group with rotation and the other without rotation

  study how patient rotation after pleurodesis affects its success by measuring pleural adherence score by chest ultrasound, a higher adhesion score means successful pleurodesis

  immediatly and after one month from pleurodesis

Secondary Outcomes (1)

• Measurement of non-verbal Pain score in patients with malignant pleural effusion candidates for pleurodesis in group with rotation and the other without rotation

  immediately after pleurodesis

Study Arms (2)

no rotation after pleurodesis

NO INTERVENTION

rotation after pleurodesis

ACTIVE COMPARATOR

Other: side to side and front to back rotation 30 minutes each

Interventions

side to side and front to back rotation 30 minutes each OTHER

side to side and front to back rotation 30 minutes each after pleurodesis

rotation after pleurodesis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who will be admitted at Chest department, Ain-Shams University Hospitals with malignant pleural effusions candidate for pleurodesis

You may not qualify if:

• Multiloculated fluid
• Previous failed pleurodesis
• Liver failure
• Renal failure
• Congestive heart failure
• Prolonged use of steroids or NSAIDs
• Refusal to participate

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams university

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Pleural Effusion, Malignant

Condition Hierarchy (Ancestors)

Pleural Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Pleural Effusion; Pleural Diseases; Respiratory Tract Diseases

Central Study Contacts

Hieba G Ezzelregal, MD

CONTACT

01002041611; hiebagamal24@med.asu.edu.eg

Ahmed M Abdelsamad

CONTACT

01008662384

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: August 4, 2025
• First Posted: August 29, 2025
• Study Start: May 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: February 1, 2026
• Last Updated: August 29, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)