Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient

NCT07796984 | Not Yet Recruiting

• 2 other identifiers: RC31/25/0562ID-RCB
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source zones. This standardized procedure, known as Stereo-Electroencephalography (SEEG), was developed in France in the 1960s. The electrodes remain implanted for several days-typically two weeks-while awaiting spontaneous epileptic seizures. During this period, the patient remains hospitalized, and their electroencephalographic activity is recorded around the clock. Patients can be asked to perform cognitive tasks (such as tasks involving memory, attention, vision, language, and decision-making) while awake or asleep; the results can then be correlated with the intracerebral electroencephalographic activity recorded simultaneously as part of their clinical care. This approach makes it possible to capture the electrophysiological signatures of specific cognitive processes, thereby enabling researchers to: 1) create a brain map of electrophysiological signatures, 2) improve standard models of cognitive function, and 3) study the dysfunction of these processes in epilepsy.

Conditions

Epilepsy

Keywords

epilepsy; cognitive task; stereoelectroencephalography

Outcome Measures

Primary Outcomes (1)

• Construction of a database of electrophysiological signatures of various cognitive functions

  Correlation of performance on a task involving a neurocognitive process with characteristics of brain activity recorded during the task (electrophysiological signature) using intracranial stereo-electroencephalography (SEEG) electrodes.

  3 weeks after the inclusion

Secondary Outcomes (2)

• Evaluation of the impact of epilepsy on these electrophysiological signatures

  3 weeks after the inclusion

• Determine whether a given brain region is dysfunctional in certain epileptic patients by comparing it with the atlas of normal physiological signatures.

  3 weeks after the inclusion

Study Arms (1)

Patients hospitalized for SEEG with cognitive tasks

Other: Cognitive tasks in the form of questionnaires

Interventions

Cognitive tasks in the form of questionnaires OTHER

During their hospitalization for SEEG, patients will perform cognitive tasks to assess memory, vision, attention, language, and decision-making.

Patients hospitalized for SEEG with cognitive tasks

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with drug-resistant epilepsy hospitalized for stereo-electroencephalography

You may qualify if:

• Patient with drug-resistant focal epilepsy undergoing SEEG evaluation as part of the pre-surgical workup for epilepsy
• Intellectual capacity sufficient to perform cognitive tasks, receive information about the study procedure, and understand the information sheet

You may not qualify if:

• Patients already participating in another research project that prohibits participation in another study

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

Electrophysiologie cérébrale, épilepsie, sommeil, Hôpital Pierre Paul Riquet

Toulouse, Oui, 31000, France

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

Jonathan Curot, PHD

CONTACT

05 61 77 94 88; curot.j@chu-toulouse.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 27, 2026
• First Posted: September 1, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): October 1, 2031
• Study Completion (Estimated): October 31, 2031
• Last Updated: September 1, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)