Comparison of Quality of Life and Changes Experienced by Patients After Epilepsy Surgery

NCT06035965 | Completed

• 1 other identifier: RC31/23/0411
• Study Type: observational
• Target: 151
• Locations: 1 country
• Sites: 1

Brief Summary

Epilepsy is one of the most common chronic neurological diseases. According to data from the World Health Organization (WHO), it affects 0.5 to 1% of the population, or around 70 million people world-wide and around 600,000 in France. There are several more or less severe forms of epilepsy depending on the type of epileptic seizures and the frequency of these seizures. About 30% of epileptic patients respond poorly to well-conducted medical treatment, which makes the number of so-called "drug-resistant" patients estimated at between 100,000 and 150,000 patients. Epilepsy surgery is possible in some cases of drug-resistant epilepsy and can lead to complete seizure control. Beyond the impact on the control of seizures, surgery can have an impact on the lives of patients at the psychological, emotional and cognitive level, with consequences on their socio-professional but also personal life. Thus the impact on the daily life of patients after epilepsy surgery can vary greatly from one patient to another and the personal feelings of operated patients do not always seem to correspond to the objective elements collected by doctors. 2.3 The investigators want to retrospectively assess the satisfaction and quality of life of patients operated on for more than 2 years based on their epileptological results (frequency of seizures).

Conditions

Epilepsy

Outcome Measures

Primary Outcomes (1)

• Evaluation of the changes felt by patients

  Evaluate the changes felt by patients more than 2 years after surgery in the context of drug-resistant epilepsy using a new questionnaire created by the epileptology team of the Toulouse University Hospital. The rating of the responses is distributed between 0 and 100 (0 = very negative change, 50 = no change and 100 = very positive change).

  2 years

Interventions

Epilepsy Surgery Satisfaction Questionnaire (ESSQ-19) OTHER

19 items assessing post-surgery satisfaction.

Quality of Life in Epilepsy Inventory (QOLIE-31) OTHER

31 items to assess different dimensions of quality of life

Generalized Anxiety Disorder 7 (GAD7) OTHER

7 items, rated from 0 to 3, to detect anxiety disorders.

Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) OTHER

to screen for depressive disorders

Evaluation of Changes in Daily Life after Epilepsy Surgery (EVOCQUE) OTHER

self-questionnaire developed by the Toulouse epileptology team in 2023 for patients who have undergone epilepsy surgery. It aims to collect the feelings of patients concerning the changes induced by surgery in their daily life according to a 7-point Likert scale.

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient operated in the context of epilepsy surgery dating back more than 2 years in the epileptology center of the Toulouse University Hospital.

You may qualify if:

• Patient operated in the context of epilepsy surgery dating back more than 2 years in the epileptology center of the Toulouse University Hospital.
• Patient covered by a social security scheme.
• Patient having given his non-objection to participate in the research.

You may not qualify if:

• Minor under the age of 15 at the time of the questionnaires.
• Serious psychiatric pathology unrelated to epilepsy surgery.
• Severe intellectual disability limiting responses to self-questionnaires.
• Language barrier.
• Patients under guardianship and protection of justice.

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

CHU de Toulouse

Toulouse, France

Location

MeSH Terms

Conditions

Epilepsy

Interventions

Quality of Life

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Health Status; Demography; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• HELENE MIRABEL

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 6, 2023
• First Posted: September 13, 2023
• Study Start: November 30, 2023
• Primary Completion: November 30, 2024
• Study Completion: November 30, 2024
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)