Diagnostic and Prognostic Roles of Procalcitonin and Highly Sensitive C-Reactive Protein in Early Detection of Burn Sepsis

NCT07791030 | Completed

• 1 other identifier: MD.25.08.1017
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate the value of procalcitonin and highly sensitive c-reactive protein as biomarkers for early detection of sepsis in patients with major burns.

Conditions

Diagnostic Role; Prognostic Role; Procalcitonin; Highly Sensitive; C-Reactive Protein; Early Detection; Burn Sepsis

Outcome Measures

Primary Outcomes (1)

• Measurement of c-reactive protein level

  Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

  5 days of burn injury

Secondary Outcomes (1)

• Measurement of procalcitonin level

  5 days of burn injury

Study Arms (1)

Study group

Patients with major burn (2nd and 3rd degrees of burn)

Diagnostic Test: Measurement of Procalcitonin level; Diagnostic Test: Measurement of c-reactive protein level

Interventions

Measurement of Procalcitonin level DIAGNOSTIC_TEST

Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Study group

Measurement of c-reactive protein level DIAGNOSTIC_TEST

Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Study group

Eligibility Criteria

• Age: 3 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is prospective study will include a total number of 30 patients with major burn. These patients will be admitted to Plastic, Reconstructive and Burn surgery center at Mansoura University from July 2025 to July 2026.

You may qualify if:

• Age from 3 years to 65 years.
• Both sexes.
• Patients with major burn (2nd and 3rd degrees of burn).

You may not qualify if:

• Patients with unrealistic expectations.
• Patients with inhalational burn injury.
• Patients with uncompensated chronic disease e.g. hepatic, renal.
• Patients with mental or psychological troubles affecting the study

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura University

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Location

MeSH Terms

Conditions

Hypersensitivity

Condition Hierarchy (Ancestors)

Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Plastic, Reconstructive and Burn Surgery Center, Faculty of Medicine, Mansoura University, Egypt

Study Record Dates

• First Submitted: August 24, 2026
• First Posted: August 27, 2026
• Study Start: September 1, 2025
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: August 27, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author

Locations

EG (1)