Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients

NCT06958354 | Completed

• 1 other identifier: 2023/34
• Study Type: observational
• Target: 1,529
• Locations: 1 country
• Sites: 1

Brief Summary

In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. Early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. Procalcitonin (PCT) is a calcitonin precursor peptide and has been reported to predict bacteremia early. While the PCT concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. In our study, our aim is to determine whether there is a relationship between serum PCT concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our Internal Intensive Care Unit.

Conditions

Sepsis; Septic; Bacteremia and Sepsis; Intensive Care Medicine; Procalcitonin

Keywords

procalcitonin; sepsis; septic shock; intrensive care medicine

Outcome Measures

Primary Outcomes (1)

• Correlation of serum PCT levels measured within 24 hours of culture in intensive care patients with bacteremia and the pathogen type (Gram-positive, Gram-negative, fungal) in the culture result.

  In patients with positive blood cultures, serum PCT values studied within the first 24 hours from the time the culture sample was taken will be evaluated retrospectively.

Secondary Outcomes (1)

• Diagnostic power of PCT levels in distinguishing Gram-negative, Gram-positive and fungal infections

  serum PCT values studied within the first 24 hours from the time the culture sample

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Among the patients who were followed up in the intensive care unit between 01.01.2018 and 01.01.2023 and who were found to have a positive blood culture during their follow up, only those whose PCT results were obtained within 24 hours, based on the time the blood culture sample was taken, will be included.

You may qualify if:

• Positive blood culture during their follow up
• Patients over 18 years of age

You may not qualify if:

• Those under the age of 18
• Those who have had surgery or trauma in the last 72 hours
• Those with a history of autoimmune disease, chronic renal failure
• Patients admitted to intensive care due to acute pancreatitis, pregnancy, burns.
• Patients with incomplete data.

Sponsors & Collaborators

• Gulhane Training and Research Hospital: lead

Study Sites (1)

Gulhane Training and Research Hospital

Ankara, Türkiye, 06010, Turkey (Türkiye)

Location

Related Publications (4)

• Muller F, Christ-Crain M, Bregenzer T, Krause M, Zimmerli W, Mueller B, Schuetz P; ProHOSP Study Group. Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest. 2010 Jul;138(1):121-9. doi: 10.1378/chest.09-2920. Epub 2010 Mar 18.

  PMID: 20299634 BACKGROUND

• Liu D, Su L, Han G, Yan P, Xie L. Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis. PLoS One. 2015 Jun 15;10(6):e0129450. doi: 10.1371/journal.pone.0129450. eCollection 2015.

  PMID: 26076027 BACKGROUND

• Leli C, Ferranti M, Moretti A, Al Dhahab ZS, Cenci E, Mencacci A. Procalcitonin levels in gram-positive, gram-negative, and fungal bloodstream infections. Dis Markers. 2015;2015:701480. doi: 10.1155/2015/701480. Epub 2015 Mar 17.

  PMID: 25852221 BACKGROUND

• https://pmc.ncbi.nlm.nih.gov/articles/PMC6289022/

  BACKGROUND

MeSH Terms

Conditions

Sepsis; Bacteremia; Shock, Septic

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bacterial Infections; Bacterial Infections and Mycoses; Shock

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist

Study Record Dates

• First Submitted: April 24, 2025
• First Posted: May 6, 2025
• Study Start: March 15, 2023
• Primary Completion: January 1, 2025
• Study Completion: October 19, 2025
• Last Updated: December 11, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR

Locations

TU (1)