Procalcitonin as a Prognostic Predictor in Patients With Acute Infectious Disease Hospitalized in the Internal Medicine Department.

NCT07770334 | Not Yet Recruiting

• 1 other identifier: BRZ-0066-26
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Procalcitonin is a well-known biomarker used to distinguish between bacterial and viral infections, assess a patient's risk category, and serve as a prognostic indicator. However, existing data are derived primarily from relatively young patients in intensive care units; there is a lack of information regarding the prognostic significance of procalcitonin in older patients hospitalized in internal medicine wards.

Conditions

Procalcitonin; Infection; Internal Medicine Patients

Keywords

Procalcitonin; CRP; Acute Infection; Internal Medicine Ward

Outcome Measures

Primary Outcomes (1)

• Mortality

  Evaluation of procalcitonin as a prognostic marker in patients hospitalized in the internal medicine and geriatric department by examining mortality during hospitalization, within 7 days and within 30 months.

  30 days

Secondary Outcomes (2)

• Additional Outcomes - Length of stay

  30 days

• Additional data - morbidity

  30 days

Study Arms (1)

Positive Procalcitonin

All patients hospitalized in internal medicine and geriatric wards with a diagnosis of acute infectious disease who underwent procalcitonin testing, starting in 2020.

Other: No Interventions

Interventions

No Interventions OTHER

No intervention, retrospective observational study

Positive Procalcitonin

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients hospitalized in internal medicine and geriatric wards with a diagnosis of acute infectious disease who underwent procalcitonin testing, starting in 2020.

You may qualify if:

• All patients hospitalized in internal medicine and geriatric wards with a diagnosis of acute infectious disease who underwent procalcitonin testing, starting in 2020.

You may not qualify if:

• Age under 18
• Causes for false positive elevated cacitonin:
• Extensive burns
• Major operation in the last 30 days
• Major trauma in the last 30 days.
• Severe pancreatitis
• Cardiogenic shock
• Small Cell Lung Cancer
• Thyroid gland malignancy

Sponsors & Collaborators

• Barzilai Medical Center: lead

Related Publications (10)

• Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii33-40. doi: 10.1093/jac/dkq523.

  PMID: 21398306 BACKGROUND

• Schuetz P, Chiappa V, Briel M, Greenwald JL. Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms. Arch Intern Med. 2011 Aug 8;171(15):1322-31. doi: 10.1001/archinternmed.2011.318.

  PMID: 21824946 BACKGROUND

• Avrillon V, Locatelli-Sanchez M, Folliet L, Carbonnaux M, Perino E, Fossard G, Desseigne M, Freymond N, Geriniere L, Perrot E, Souquet PJ, Couraud S. Lung cancer may increase serum procalcitonin level. Infect Disord Drug Targets. 2015;15(1):57-63. doi: 10.2174/1871526515666150320162950.

  PMID: 25809625 BACKGROUND

• Schupp T, Weidner K, Rusnak J, Jawhar S, Forner J, Dulatahu F, Dudda J, Bruck LM, Hoffmann U, Bertsch T, Akin I, Behnes M. C-reactive protein and procalcitonin during course of sepsis and septic shock. Ir J Med Sci. 2024 Feb;193(1):457-468. doi: 10.1007/s11845-023-03385-8. Epub 2023 May 19.

  PMID: 37204560 BACKGROUND

• Rajkumari N, Mathur P, Sharma S, Gupta B, Bhoi S, Misra MC. Procalcitonin as a predictor of sepsis and outcome in severe trauma patients: a prospective study. J Lab Physicians. 2013 Jul;5(2):100-8. doi: 10.4103/0974-2727.119852.

  PMID: 24701102 BACKGROUND

• Daud M, Khan MB, Qudrat QU, Ullah I, Khan S, Khan MZ, Yousuf I, Ahmad F. Role of C-reactive Protein and Procalcitonin in Early Diagnostic Accuracy and Their Prognostic Significance in Sepsis. Cureus. 2024 Sep 27;16(9):e70358. doi: 10.7759/cureus.70358. eCollection 2024 Sep.

  PMID: 39469363 BACKGROUND

• Jain S, Sinha S, Sharma SK, Samantaray JC, Aggrawal P, Vikram NK, Biswas A, Sood S, Goel M, Das M, Vishnubhatla S, Khan N. Procalcitonin as a prognostic marker for sepsis: a prospective observational study. BMC Res Notes. 2014 Jul 17;7:458. doi: 10.1186/1756-0500-7-458.

  PMID: 25034373 BACKGROUND

• Juneja D, Jain N, Singh O, Goel A, Arora S. Comparison between presepsin, procalcitonin, and CRP as biomarkers to diagnose sepsis in critically ill patients. J Anaesthesiol Clin Pharmacol. 2023 Jul-Sep;39(3):458-462. doi: 10.4103/joacp.joacp_560_21. Epub 2023 May 29.

  PMID: 38025554 BACKGROUND

• Zincircioglu C, Rollas K, Guldogan IK, Saritas A, Ozkarakas H, Ersan G, Senoglu N. Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients. Turk J Med Sci. 2021 Oct;51(5):2649-2656. doi: 10.3906/sag-2007-268. Epub 2021 Oct 21.

  PMID: 34344141 BACKGROUND

• Gregoriano C, Heilmann E, Molitor A, Schuetz P. Role of procalcitonin use in the management of sepsis. J Thorac Dis. 2020 Feb;12(Suppl 1):S5-S15. doi: 10.21037/jtd.2019.11.63.

  PMID: 32148921 BACKGROUND

MeSH Terms

Conditions

Infections

Study Officials

• Daniel Leshin Carmel, MD

  Barzilai Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Daniel Leshin Carmel Head of Infection Prevention and Control, MD

CONTACT

+972525253037; danielles@bmc.gov.il

Pnina Nir

CONTACT

pninan@bmc.gov.il

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Infection Control and Prevention Unit

Study Record Dates

• First Submitted: August 10, 2026
• First Posted: August 18, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 18, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share