Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

NCT07200817 | Recruiting

• 1 other identifier: FMASU MD224/2024
• Study Type: observational
• Target: 290
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

Conditions

Neutrophils to Lymphocytes; Platelets; Procalcitonin; Total Leucocytic Count; Prognostic Outcome; Septic Patients; Intensive Care Unit

Outcome Measures

Primary Outcomes (1)

• Levels of Neutrophils to Lymphocytes and Platelets ratio

  The ratio of neutrophils to Lymphocytes and Platelets in relation to 28-day mortality among septic patients will be recorded.

  28 days post-procedure

Secondary Outcomes (2)

• Procalcitonin (PCT)

  28 days post-procedure

• Total Leukocytic Count (TLC)

  28 days post-procedure

Study Arms (1)

Study group

Septic patients (under the third international consensus definitions of sepsis and septic shock)

Diagnostic Test: Neutrophils to Lymphocytes and Platelets ratio (N/LP)

Interventions

Neutrophils to Lymphocytes and Platelets ratio (N/LP) DIAGNOSTIC_TEST

The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured

Study group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A prospective observational study will be conducted at Ain Shams University Hospital, Cairo, Egypt.

You may qualify if:

• Age from 18 to 70 years old.
• Both sexes.
• Septic patients (under the third international consensus definitions of sepsis and septic shock).

You may not qualify if:

• Pregnancy
• Malignancy
• On immunosuppressive therapy
• Hematological Disorders
• Major Trauma
• Major Burns
• Child-Pugh Class C Liver Cirrhosis
• On Hemodialysis

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, 11591, Egypt

RECRUITING

Central Study Contacts

Michael G Farag, Master

CONTACT

00201278142328; MICHAELFARAG@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Egypt.

Study Record Dates

• First Submitted: September 23, 2025
• First Posted: October 1, 2025
• Study Start: September 20, 2024
• Primary Completion: March 19, 2026
• Study Completion: March 19, 2026
• Last Updated: October 1, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)