Comparison of the Effect of Eight Weeks of Electrical Muscle Stimulation (EMS) Versus Resistance Training on Oxidative Stress Indicators and Cellular Health Index in Overweight and Obese Women
Sponsor study identifier
interventional
42
1 country
1
Study Start
September 15, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 15, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
November 25, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study aims to compare the effects of eight weeks of resistance training versus electrical muscle stimulation (EMS) on oxidative stress indicators and cellular health index in overweight and obese women aged 35-45 years. Forty-two participants will be randomly assigned to three groups: resistance training, EMS, and control. The resistance training group will perform progressive resistance exercises three times per week for eight weeks. The EMS group will receive electrical muscle stimulation on biceps, abdominal, back, and quadriceps muscles three times per week for eight weeks. The control group will receive no intervention. Oxidative stress markers including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), glutathione, protein carbonyl (PC), and total antioxidant capacity (TAC) will be measured from blood samples. Cellular health will be assessed using phase angle (PhA) derived from bioelectrical impedance analysis. Upper and lower body muscular strength and endurance will also be evaluated. All measurements will be taken at baseline and 48 hours after the last training session. The primary outcome is change in phase angle. Secondary outcomes include changes in oxidative stress markers and physical performance.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 25, 2026
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 16, 2026
Actual (reported)August 26, 2026
Actual (reported)September 15, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 15, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
November 25, 2026
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Change in Phase Angle (PhA) as a Cellular Health Index
Phase angle (PhA) measured using bioelectrical impedance analysis (Inbody770). PhA is calculated as the ratio of reactance (Xc) to resistance (R) and serves as an indicator of cellular health, membrane integrity, and cell function.
Measured at baseline (before intervention) and 48 hours after the last training session (week 8).
Change in Serum Superoxide Dismutase (SOD)
Measured at baseline (before intervention) and 48 hours after the last training session (week 8).
Change in Upper Body Strength (Bench Press 1RM)
Measured at baseline (before intervention) and 48 hours after the last training session (week 8).
Change in Lower Body Strength (Squat 1RM)
Measured at baseline (before intervention) and 48 hours after the last training session (week 8).
Change in Upper Body Muscular Endurance (Push-Up Test)
Measured at baseline (before intervention) and 48 hours after the last training session (week 8).
Change in Serum Glutathione Peroxidase (GPX)
Measured at baseline (before intervention) and 48 hours after the last training session (week
Eight weeks of progressive resistance training, 3 sessions per week. Each session includes upper body, back, abdominal, and lower body exercises. Training intensity progresses from 60% of 1RM in week 1 to 85% of 1RM in week 8.
Eight weeks of electrical muscle stimulation training, 3 sessions per week. EMS applied to biceps brachii, abdominals, back, and quadriceps muscles using frequency of 35-70 Hz, pulse duration 100 μs, and pulse period 50 ms. Electrode size: 150 × 240 mm. Intensity progressively increased over 8 weeks.
Progressive resistance training program including upper body (chest press), back (lat pulldown), abdominal (crunch), and lower body (squat) exercises. Performed 3 times per week for 8 weeks. Each session includes warm-up (10 min), main exercises (30 min), and cool-down (10 min). Intensity: 60-85% of 1RM, progressing weekly.
Electrical muscle stimulation applied to biceps brachii, abdominals, back, and quadriceps muscles using a commercial EMS device. Parameters: frequency 35-70 Hz, pulse duration 100 μs, pulse period 50 ms, electrode size 150 × 240 mm. Performed 3 times per week for 8 weeks, 15 minutes per session. Intensity progressively increased based on participant tolerance.
Faculty of Sport Sciences, University of Birjand
Birjand, South Khorasan Province, 9717434765, Iran
Mohsen Mohammadnia Ahmadi, PhD
university of birjand
First Submitted
August 16, 2026
First Posted
August 26, 2026
Study Start
No exercise intervention during the 8-week study period. Participants are asked to maintain their usual lifestyle and physical activity levels.
Participants in the control group receive no exercise intervention during the 8-week study period.
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September 15, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 15, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
November 25, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 26, 2026
Record last verified: 2026-08
There is no plan to share individual participant data (IPD) due to ethical and privacy restrictions, as the data contain sensitive personal and physiological information of the participants. Additionally, informed consent was obtained only for the primary study objectives and does not cover secondary data sharing
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