Effect of High-intensity Interval Training on Cardiometabolic Health and Physical Fitness in Young Adults With Obesity

NCT07283406 | Enrolling By Invitation DMC

• 1 other identifier: CUTLAJO251028
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of the present project is to compare the effects of two types of training on cardiovascular health components and physical fitness in young adults with obesity.

Conditions

Obesity & Overweight

Keywords

obesity; HIIT; MICT

Outcome Measures

Primary Outcomes (16)

• Maximum oxygen uptake (VO₂max)

  VO₂max (ml/min/kg): Change from Baseline at 12 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol

  Baseline and after 12 weeks

• Weight

  Weight (kg): Changes in weight from baseline to 12 weeks of intervention.

  Baseline and after 12 weeks

• Height

  Height (cm): Changes in height from baseline to 12 weeks of intervention.

  Baseline and after 12 weeks

• Body mass index (BMI)

  BMI (kg/m2): Change from Baseline at 12 weeks, calculated by: weight (kg)/ height (m\^2)

  Baseline and after 12 weeks

• Body fat percentage

  Body fat percentage (%): Changes in body fat assessed by bioelectrical impedance analysis (BIA)

  Baseline and after 12 weeks

• Muscle mass percentage

  Muscle mass percentage (%): Changes in muscle mass measured using bioelectrical impedance analysis (BIA)

  Baseline and after 12 weeks

• Waist circumference

  Waist circumference (cm): Changes in waist circumference will be measured using a Lufkin measuring tape (USA) following the guidelines of the International Society for the Advancement of Kinanthropometry (ISAK)

  Baseline and after 12 weeks

• Waist-to-hip ratio

  Waist-to-hip ratio: Changes in waist-to-hip ratio will be calculated by dividing the waist measurement by the hip measurement

  Baseline and after 12 weeks

• Glucose

  Glucose (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• Triglycerides

  Triglycerides (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• Total cholesterol

  Total cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• HDL cholesterol

  HDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• LDL cholesterol

  LDL cholesterol (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• C-reactive protein (CRP)

  CRP (mg/dl): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• Systolic blood pressure (SBP)

  SBP (mmHg): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

• Diastolic blood pressure (DBP)

  DBP (mmHg): Changes from baseline to 12 weeks of intervention

  Baseline and after 12 weeks

Study Arms (2)

HIIT Group

EXPERIMENTAL

This group will train for 12 weeks

Other: High-intensity interval training intervention; Other: Educational sessions

MICT Group

ACTIVE COMPARATOR

This group will train for 12 weeks

Other: Moderate-intensity continuous training intervention; Other: Educational sessions

Interventions

High-intensity interval training intervention OTHER

The HIIT group will undergo training for 12 weeks, with a frequency of three sessions per week, completing a total of 36 sessions. Each session will include a 5-minute warm-up and a 5-minute cool-down at 50-60% of maximum heart rate (HRmax). The training protocol will consist of 2-minute high-intensity intervals performed at 90-95% HRmax, corresponding to a Borg rating of perceived exertion (RPE) of 17-18, alternated with 2-minute recovery periods at 70% HRmax (RPE 12-14). A total of five intervals will be completed per session, resulting in an overall high-intensity workload of 18 minutes. All training sessions will be conducted on a stationary cycle ergometer

HIIT Group

Moderate-intensity continuous training intervention OTHER

The MICT group will perform moderate-intensity continuous training at 60-70% HRmax, corresponding to an RPE of 12-14, for 35-45 minutes on a stationary cycleergometer. Heart rate and physical activity levels will be continuously monitored in both groups using a chest-strap heart rate sensor (Polar H9, Polar Electro, Finland).

MICT Group

Educational sessions OTHER

In addition, four educational sessions will be conducted to provide dietary recommendations to all participants. These sessions will aim to promote balanced eating habits and to discourage the excessive consumption of ultra-processed foods or alcohol, as these factors could interfere with the intervention outcomes.

HIIT Group; MICT Group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Young adults
• BMI ≥ 30 kg/m\^2" and \< 40 kg/m\^2
• Signed informed consent form

You may not qualify if:

• Participants who smoke
• Clinical diagnosis of hypothyroidism
• Clinical diagnosis of type 1 diabetes mellitus
• Clinical diagnosis of type 2 diabetes mellitus
• Clinical diagnosis of grade 3 obesity
• Clinical diagnosis of hypertension
• Clinical diagnosis of acute myocardial infarction or angina pectoris
• Use of nitrates and calcium channel blockers within 4 days prior to the start of the study
• Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention
• Pregnant women
• Breastfeeding women
• Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day
• Postural and biomechanical disorders (knee, foot, and spine)

Sponsors & Collaborators

• Centro Universitario de Tlajomulco, Universidad de Guadalajara: lead

Study Sites (1)

Centro Universitario de Tlajomulco, Universidad de Guadalajara

Guadalajara, Jalisco, 45650, Mexico

Location

MeSH Terms

Conditions

Obesity; Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: December 15, 2025
• Study Start: January 3, 2026
• Primary Completion: January 15, 2026
• Study Completion: April 1, 2026
• Last Updated: December 15, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)