Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity

NCT07444736 | Enrolling By Invitation DMC

• 1 other identifier: CUTLAJO260219
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.

Conditions

Obesity & Overweight

Keywords

Obesity; Exercise

Outcome Measures

Primary Outcomes (23)

• Muscle strength

  Muscle strength (kg): Change from baseline to 8 weeks of intervention. Muscle strength will be assessed using dynamometry

  Baseline and after 8 weeks

• Dynamic muscle strength

  Dynamic muscle strength (kg): Change from baseline to 8 weeks of intervention.

  Baseline and after 8 weeks

• Arm circumference

  Arm circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol

  Baseline and after 8 weeks

• Thigh circumference

  Thigh circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol

  Baseline and after 8 weeks

• Maximum oxygen uptake (VO₂max)

  VO₂max (ml/min/kg): Change from Baseline at 8 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol

  Baseline and after 8 weeks

• Systolic blood pressure (SBP)

  SBP (mmHg): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Diastolic blood pressure (DBP)

  DBP (mmHg): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Heart rate

  Heart rate (bpm): Change from baseline to 8 weeks of intervention.

  Baseline and after 8 weeks

• Glucose

  Glucose (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Triglycerides

  Triglycerides (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Total cholesterol

  Total cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• HDL cholesterol

  HDL cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• LDL cholesterol

  LDL cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• C-reactive protein (CRP)

  CRP (mg/dl): Changes from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Interleukin-6 (IL-6)

  IL-6 (pg/mL):Change from baseline to 8 weeks of intervention.

  Baseline and after 8 weeks

• Tumor Necrosis Factor Alpha (TNF-α)

  TNF-α (pg/mL): Change from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Weight

  Weight (kg): Changes in weight from baseline to 8 weeks of intervention.

  Baseline and after 8 weeks

• Height

  Height (cm): Changes in height from baseline to 8 weeks of intervention

  Baseline and after 8 weeks

• Body mass index (BMI)

  BMI (kg/m\^2): Change from Baseline at 8 weeks, calculated by: weight (kg)/ height (m\^2).

  Baseline and after 8 weeks

• Body fat percentage

  Body fat percentage (%): Changes in body fat assessed by bioelectrical impedance analysis (BIA)

  Baseline and after 8 weeks

• Muscle mass percentage

  Muscle mass percentage (%): Changes in muscle mass measured using bioelectrical impedance analysis (BIA)

  Baseline and after 8 weeks

• Perceived Exertion

  Perceived exertion will be assessed using the Rating of Perceived Exertion Scale (RPE)

  Baseline and after 8 weeks

• Exercise enjoyment

  Exercise enjoyment will be assessed using the validated Physical Activity Enjoyment Scale Questionnaire (PACES)

  Baseline and after 8 weeks

Study Arms (2)

BFR group

EXPERIMENTAL

This group will train for 8 weeks

Other: Intervention

Control group

ACTIVE COMPARATOR

This group will train for 8 weeks

Other: Intervention

Interventions

Intervention OTHER

The BFR group will perform machine-based quadriceps extension exercises and dumbbell biceps curls involving both lower limbs and both upper limbs. Each exercise will consist of 4 sets of 12 repetitions. Quadriceps extensions will be performed at an intensity of 40% of one-repetition maximum (1RM), and biceps curls at 20% of 1RM. The execution cadence will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase. Inter-set rest intervals will be 1 minute. For vascular occlusion, a Carbafix cuff (8 cm width × 68 cm length for the upper limb; 10.5 cm width × 106.0 cm length for the lower limb) will be applied directly to the skin at the most proximal portion of the arm or thigh. The cuff will be inflated to 20 mmHg above resting brachial systolic blood pressure. To ensure partial vascular occlusion, pulse and oxygen saturation will be assessed using a pulse oximeter at the end of each set. Cuff pressure will be released during the inter-set rest periods.

BFR group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18 to 40
• Both genders
• BMI ≥ 30 kg/m\^2 and \< 40 kg/m\^2
• Signed informed consent form

You may not qualify if:

• Participants who smoke
• Personal and family history of vascular disease or deep vein thrombosis
• Clinical diagnosis of hypothyroidism
• Clinical diagnosis of type 1 diabetes mellitus
• Clinical diagnosis of type 2 diabetes mellitus
• Clinical diagnosis of grade 3 obesity
• Clinical diagnosis of hypertension
• Clinical diagnosis of acute myocardial infarction or angina pectoris
• Use of nitrates and calcium channel blockers within 4 days prior to the start of the study
• Use of anticoagulants
• Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention
• Pregnant women
• Breastfeeding women
• Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day
• Postural and biomechanical disorders (knee, foot, and spine)

Sponsors & Collaborators

• Centro Universitario de Tlajomulco, Universidad de Guadalajara: lead

Study Sites (1)

Centro Universitario de Tlajomulco

Tlajomulco de Zúñiga, Jalisco, 45650, Mexico

Location

MeSH Terms

Conditions

Obesity; Overweight; Motor Activity

Interventions

Methods

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 25, 2026
• First Posted: March 3, 2026
• Study Start: February 1, 2026
• Primary Completion: March 15, 2026
• Study Completion: May 15, 2026
• Last Updated: March 3, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)