Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis

NCT07784998 | Recruiting DMC

• 1 other identifier: 189-26
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

This comparative experimental study aims to evaluate the effectiveness of Sensory-Modulated Graded Weight-Bearing Physiotherapy (SMGWBP) in patients with knee osteoarthritis and compare treatment outcomes between male and female participants. Participants will receive a 6-week physiotherapy program with assessments conducted at baseline (pre-intervention), mid-intervention (3 weeks), and post-intervention (6 weeks) using validated outcome measures.

Conditions

Knee Osteoarthristis

Keywords

Knee Osteoarthritis; Sensory-Modulated Graded Weight-Bearing Physiotherapy; Physiotherapy; Rehabilitation; Pain; WOMAC; Proprioception; Six-Minute Walk Test; SF-36; Gender Differences

Outcome Measures

Primary Outcomes (4)

• Change in Pain Intensity Measured by the Visual Analog Scale

  To evaluate the change in pain intensity following a 6-week Sensory-Modulated Graded Weight Bearing Physiotherapy program in patients with knee osteoarthritis.

  Baseline, Week 3, and Week 6

• Change in Physical Function Measured by the Western Ontario and McMaster Universities Osteoarthritis Index

  To assess changes in physical function following Sensory-Modulated Graded Weight-Bearing Physiotherapy.

  Baseline, Week 3, and Week 6

• Change in Proprioception Measured by the Joint Position Sense (JPS) Test

  To assess changes in knee joint proprioception following Sensory Modulated Graded Weight-Bearing Physiotherapy

  Baseline, Week 3, and Week 6

• Change in Gait Performance Measured by the Six-Minute Walk Test (6MWT)

  To assess changes in gait performance following Sensory Modulated Graded Weight-Bearing Physiotherapy

  Baseline, Week 3, and Week 6

Secondary Outcomes (2)

• Change in Health-Related Quality of Life Measured by the Short Form-36 (SF-36)

  Baseline, Week 3, and Week 6

• Treatment Compliance

  At the end of the 6 week intervention

Study Arms (2)

Arm 1 - Arm Title: Male Participants

EXPERIMENTAL

Twenty-six male participants with knee osteoarthritis will receive the Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme for six weeks, with three supervised sessions per week. Outcomes will be assessed at baseline, Week 3, and Week 6.

Behavioral: Sensory-Modulated Graded Weight-Bearing Physiotherapy

Arm 2 - Arm Title: Female Participants

EXPERIMENTAL

Twenty-six female participants with knee osteoarthritis will receive the Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme for six weeks, with three supervised sessions per week. Outcomes will be assessed at baseline, Week 3, and Week 6.

Behavioral: Sensory-Modulated Graded Weight-Bearing Physiotherapy

Interventions

Sensory-Modulated Graded Weight-Bearing Physiotherapy BEHAVIORAL

A structured six-week Sensory-Modulated Graded Weight-Bearing Physiotherapy Programme consisting of three supervised sessions per week (18 sessions total). Each session includes warm-up, sensory modulation, proprioceptive training, graded weight-bearing strengthening, functional mobility exercises, and cool-down activities. The programme progresses through three phases: Weeks 1-2 focus on sensory activation and proprioceptive training; Weeks 3-4 on graded weight-bearing strengthening; and Weeks 5-6 on functional weight-bearing integration. Exercises are progressed according to participant tolerance, pain severity, and functional performance. Both male and female groups receive the same intervention.

Arm 1 - Arm Title: Male Participants; Arm 2 - Arm Title: Female Participants

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 40 and 60 years.
• Diagnosed with Grade II or Grade III Knee Osteoarthritis according to Kellgren-Lawrence Classification.
• Ability to ambulate independently without assistive devices.
• Mild to moderate pain intensity with a Visual Analogue Scale score less than seven.
• Ability to understand and follow instructions.

You may not qualify if:

• Participants are excluded if they meet any of the following criteria:
• History of knee surgery within the previous six months.
• Neurological disorders affecting balance, gait, or proprioception.
• Severe cardiovascular disease limiting participation in exercise.
• Rheumatoid arthritis or other inflammatory arthritic conditions.
• Severe cognitive impairment.
• Any medical condition that contraindicates participation in rehabilitation exercises.

Sponsors & Collaborators

• Shifa Tameer-e-Millat University: lead

Study Sites (1)

T.H.Q hospital

Gujar Khan, Punjab Province, Pakistan

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee; Pain

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: This study will evaluate the effect of Sensory Modulated Graded Weight Bearing Physiotherapy and compare the treatment response between male and female participants. The study will include two parallel groups: a male group and a female group. Both groups will receive the same physiotherapy intervention for 6 weeks. Outcomes will be assessed before and after the intervention to determine whether the effectiveness of the intervention differs between male and female participants.

Study Record Dates

• First Submitted: August 17, 2026
• First Posted: August 25, 2026
• Study Start: July 13, 2026
• Primary Completion: August 24, 2026
• Study Completion (Estimated): September 23, 2026
• Last Updated: August 25, 2026

Record last verified: 2026-08

Locations

PA (1)