Ultrasound Duration Effects on Knee Osteoarthritis Pain and Function

NCT07057869 | Completed

• 1 other identifier: KaratayMST-2
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of different ultrasound treatment durations on pain and physical function in patients with knee osteoarthritis. Sixty sedentary volunteers aged 18-85 with diagnosed knee osteoarthritis will be randomly assigned to three groups receiving ultrasound therapy for 5, 10, or 15 minutes, respectively, alongside conventional treatment. Pain and physical function will be assessed using the Visual Analog Scale (VAS), WOMAC Osteoarthritis Index, and 2-minute walk test at baseline and after 4 weeks of treatment. The results will help determine the optimal ultrasound treatment duration for improving symptoms in knee osteoarthritis patients.

Conditions

Knee Osteoarthristis

Keywords

Knee Osteoarthritis, Ultrasound Therapy, Pain Management, Physical Function

Outcome Measures

Primary Outcomes (2)

• Pain Intensity (VAS)

  Assessment of knee pain intensity using the Visual Analog Scale (VAS) at baseline and after 4 weeks of treatment.

  Baseline, 4 weeks

• Physical Function (WOMAC)

  Evaluation of physical function and stiffness using the WOMAC index at baseline and after 4 weeks of treatment.

  Baseline, 4 weeks

Secondary Outcomes (1)

• Walking Distance (2-Min Walk)

  Baseline, 4 weeks

Study Arms (3)

5-minute Ultrasound Group

EXPERIMENTAL

Patients receive 5 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Procedure: 5-minute Ultrasound Group

10-minute Ultrasound Group

EXPERIMENTAL

Patients receive 10 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Procedure: 10-minute Ultrasound Group

15-minute Ultrasound Group

EXPERIMENTAL

Patients receive 15 minutes of pulsed ultrasound therapy (1 W/cm², 1 MHz) alongside conventional treatment for 4 weeks.

Procedure: 15-minute Ultrasound Group

Interventions

5-minute Ultrasound Group PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 5 minutes per session, 4 weeks duration.

5-minute Ultrasound Group

10-minute Ultrasound Group PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 10 minutes per session, 4 weeks duration.

10-minute Ultrasound Group

15-minute Ultrasound Group PROCEDURE

Pulsed ultrasound therapy applied at 1 W/cm² intensity and 1 MHz frequency for 15 minutes per session, 4 weeks duration.

15-minute Ultrasound Group

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals aged between 18 and 85 years Diagnosed with knee osteoarthritis Recommended for ultrasound therapy as part of routine physical therapy Willing to participate voluntarily and provide written informed consent

You may not qualify if:

• History of acute knee trauma Individuals with contraindications to ultrasound therapy

Sponsors & Collaborators

• KTO Karatay University: lead

Study Sites (1)

KTO Karatay Üniversitesi

Konya, 42080, Turkey (Türkiye)

Location

Related Publications (5)

• Eyigor S, Karapolat H, Ibisoglu U, Durmaz B. [Does transcutaneous electrical nerve stimulation or therapeutic ultrasound increase the effectiveness of exercise for knee osteoarthritis: a randomized controlled study]. Agri. 2008 Jan;20(1):32-40. Turkish.

  PMID: 18338277 RESULT

• Paget C, Chow MT, Duret H, Mattarollo SR, Smyth MJ. Role of gammadelta T cells in alpha-galactosylceramide-mediated immunity. J Immunol. 2012 Apr 15;188(8):3928-39. doi: 10.4049/jimmunol.1103582. Epub 2012 Mar 12.

  PMID: 22412194 RESULT

• Rutjes AW, Nuesch E, Sterchi R, Juni P. Therapeutic ultrasound for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD003132. doi: 10.1002/14651858.CD003132.pub2.

  PMID: 20091539 RESULT

• Huang MH, Lin YS, Lee CL, Yang RC. Use of ultrasound to increase effectiveness of isokinetic exercise for knee osteoarthritis. Arch Phys Med Rehabil. 2005 Aug;86(8):1545-51. doi: 10.1016/j.apmr.2005.02.007.

  PMID: 16084806 RESULT

• Cetin N, Aytar A, Atalay A, Akman MN. Comparing hot pack, short-wave diathermy, ultrasound, and TENS on isokinetic strength, pain, and functional status of women with osteoarthritic knees: a single-blind, randomized, controlled trial. Am J Phys Med Rehabil. 2008 Jun;87(6):443-51. doi: 10.1097/PHM.0b013e318174e467.

  PMID: 18496246 RESULT

MeSH Terms

Conditions

Osteoarthritis, Knee; Agnosia

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This study is an open-label trial where both patients and treating physiotherapists are aware of the ultrasound treatment duration. Outcome assessors are blinded to group assignments to reduce assessment bias.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: This is a randomized controlled trial where 60 patients with knee osteoarthritis are randomly assigned to three groups receiving ultrasound therapy for 5, 10, or 15 minutes respectively. All groups receive conventional treatment alongside ultrasound therapy. The effects on pain and physical function are evaluated before and after a 4-week treatment period.

Study Record Dates

• First Submitted: June 30, 2025
• First Posted: July 10, 2025
• Study Start: May 1, 2025
• Primary Completion: June 20, 2025
• Study Completion: June 30, 2025
• Last Updated: July 10, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)