Blood Flow Restriction Training in Knee Osteoarthritic Patients

NCT07402408 | Not Yet Recruiting

• 1 other identifier: Riphah/RCRAHS/REC/MS-PT/02171
• Study Type: interventional
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient's ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, 23 subjects in each group. knee extension and knee press exercises will be performed. In group A floss band was tied on thigh and in group B pneumatic cuff was applied on thigh. 40-60 years individual with knee osteoarthritis will be included. outcome measures will be assessed at baseline, after 1st session, after 2nd week and after 4th week.

Conditions

Knee Osteoarthristis

Keywords

Blood flow restriction therapy; Knee Osteoarthritis; Range of Motion

Outcome Measures

Primary Outcomes (1)

• Numeric Pain Rating Scale (NPRS)

  Changes from baseline will be assessed using NPRS scale. It is a one-dimensional measure of pain severity in adults including those suffering from chronic pain. Scale has ratings of 0 to 10, with higher points indicating higher levels of pain severity. it is a valid tool for assessing pain in knee OA patients.

  4th week

Secondary Outcomes (6)

• Knee Flexion Range of motion

  4th week

• Knee Extension Range of Motion

  4th week

• Quadriceps strength (dynamometer)

  4th week

• Western Ontario and McMaster Universities (WOMAC) index

  4th week

• 30 Second Sit to Stand Test (STS)

  4th week

Study Arms (2)

Blood flow restriction with Floss band (group A)

EXPERIMENTAL

seated knee extension and knee press while floss band is tied at proximal thigh.

Other: Blood flow restriction training with Floss band

Blood flow restriction with pneumatic cuff (group B)

EXPERIMENTAL

seated knee extension and knee press exercises with pneumatic cuff tied at proximal thigh

Other: Blood flow restriction training with pneumatic cuff

Interventions

Blood flow restriction training with Floss band OTHER

seated knee extension exercise and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Floss band was tied at proximal thigh with 50% stretch in proximal to distal direction starting from above the patella and moving towards groin.

Blood flow restriction with Floss band (group A)

Blood flow restriction training with pneumatic cuff OTHER

seated knee extension exercises and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Clinical cuff was tied at proximal thigh with 40% of limb occlusion pressure.

Blood flow restriction with pneumatic cuff (group B)

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 40-60 years
• Pain more than or equal to 3 on NPRS
• Range of motion ≤ 100-degree flexion and ≤ 0-degree extension
• Those who have knee osteoarthritis, according to KL (Grade 1 and 2)
• Genders: Male and Female

You may not qualify if:

• Cardiovascular condition e.g., hypertension, thromboembolism, lymphatic diseases etc.
• Muscle/tendon/ ligament injuries
• Any surgery, skin infection, trauma, pregnancy, fracture and fall
• Patient with intra articular steroidal therapy with in last 6 months
• Patient unwilling to participate and comply with the study session

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Pakistan Institute of Medical Sciences (P.I.M.S.)

Islamabad, Federal, 44000, Pakistan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Blood Flow Restriction Therapy

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Officials

• Muhammad Affan Iqbal, PhD*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, PhD

CONTACT

03324390125; imran.amjad@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 4, 2026
• First Posted: February 11, 2026
• Study Start: March 1, 2026
• Primary Completion: June 15, 2026
• Study Completion (Estimated): June 25, 2026
• Last Updated: March 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)