Carotid Doppler Changes After Passive Leg Raising for Prediction of Post-Induction Hypotension in Gastrointestinal Tumor Surgery

NCT07777159 | Not Yet Recruiting

• 1 other identifier: TABED 1-26-2663
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid artery Doppler parameters.

Conditions

Post-induction Hypotension (PIH); Gastrointestinal Tumor Surgery

Keywords

Carotid Doppler; Passive Leg Raise; Post-induction Hypotension; Anesthesia İnduction

Outcome Measures

Primary Outcomes (1)

• Predictive performance of dynamic changes in carotid Doppler parameters (ΔVTI, ΔPSV, ΔFTc) for post-induction hypotension

  Evaluation of the predictive performance of percentage changes in carotid artery velocity time integral (ΔVTI), peak systolic velocity (ΔPSV), and corrected flow time (ΔFTc) after passive leg raising maneuver for post-induction hypotension

  From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction

Secondary Outcomes (4)

• Association of baseline carotid Doppler parameters with post-induction hypotension

  From pre-induction assessment to 20 minutes after general anesthesia induction

• Cut-off values of changes in carotid Doppler parameters for prediction of post-induction hypotension

  From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction

• Association of carotid Doppler changes with duration and severity of hypotension

  From general anesthesia induction to 20 minutes post-induction

• Association of carotid Doppler changes with vasopressor requirement

  From general anesthesia induction to 20 minutes post-induction

Study Arms (1)

Elective Gastrointestinal tumor surgery group

Patients scheduled for elective gastrointestinal tumor surgery under general anesthesia who undergo preoperative carotid Doppler assessment and a passive leg raising (PLR) maneuver

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18 years or older who are scheduled for elective gastrointestinal tumor surgery under general anesthesia. Eligible participants will be ASA physical status I-III and have a BMI \<40 kg/m². Both sexes will be eligible.

You may qualify if:

• Adults aged 18 years or older
• Patients scheduled for elective gastrointestinal tumor surgery
• Surgery planned under general anesthesia
• Body mass index (BMI) \<40 kg/m²
• Written informed consent provided

You may not qualify if:

• Refusal to participate or inability to obtain written informed consent
• BMI ≥40 kg/m²
• Pregnancy
• Emergency surgery
• Difficult intubation
• ASA physical status ≥IV
• Pediatric patients (\<18 years)
• Inability to perform carotid Doppler measurements
• Arrhythmia other than continuous sinus rhythm or uncontrolled cardiac arrhythmia
• Severe cardiac dysfunction or left ventricular ejection fraction \<40%
• Severe valvular heart disease
• Clinically significant autonomic nervous system disorders
• Inadequate noninvasive blood pressure monitoring or inability to obtain the required hemodynamic measurements
• Active sepsis or systemic inflammatory syndrome
• Severe peripheral vascular disease or significant carotid artery stenosis (\>50%)

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, 06100, Turkey (Türkiye)

Location

Related Publications (2)

• Chowdhury AR, Thakuria R, Maitra S, Nath S, Baidya DK, Subramanium R, Anand RK, Kayina CA. Carotid artery corrected flow time and respiratory variation of blood flow peak velocity for prediction of hypotension after induction of general anesthesia in adult patients undergoing emergency laparotomy for peritonitis: A prospective, observational study. J Anaesthesiol Clin Pharmacol. 2023 Jul-Sep;39(3):444-450. doi: 10.4103/joacp.joacp_372_21. Epub 2023 May 5.

  PMID: 38025582 BACKGROUND

• Wang J, Li Y, Su H, Zhao J, Tu F. Carotid artery corrected flow time and respiratory variations of peak blood flow velocity for prediction of hypotension after induction of general anesthesia in elderly patients. BMC Geriatr. 2022 Nov 19;22(1):882. doi: 10.1186/s12877-022-03619-x.

  PMID: 36402973 BACKGROUND

Central Study Contacts

Seçilnaz Ünlü Tuncer, MD

CONTACT

+90 553 177 36 18; secilnaz.unlu@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 17, 2026
• First Posted: August 20, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: August 20, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)