Frequency of Electrical Acupoint Stimulation on Hypotension During Induction

NCT07433218 | Not Yet Recruiting

• 1 other identifier: XJH-A-20260220
• Study Type: interventional
• Target: 204
• Locations: 0 countries
• Sites: N/A

Brief Summary

From 15 minutes before to 15 minutes after anesthesia, Transcutaneous Electrical Acupoint Stimulation(TEAS) at different frequencies will be applied at Neiguan and Jian Shi. The changes in blood pressure during the anesthesia induction period will be compared among the high-frequency group ,the low-frequency group and the control group to explore the better frequency to reduce the incidence of post-induction hypotension(PIH) in the elderly.

Conditions

Post-induction Hypotension (PIH); Transcutaneous Electrical Acupoint Stimulation; Anesthesia

Keywords

transcutaneous electrical acupoint stimulation; frequency; hemodynamic stability

Outcome Measures

Primary Outcomes (1)

• incidence of hypotension

  Hypotension is defined as a Mean arterial pressure (MAP) reduction of more than 20% from baseline or a MAP less than 65 mm Hg for at least 30 seconds. The baseline MAP is measured during the 5 minutes before start of intervention

  from start of anesthesia induction to 15 minutes after induction

Secondary Outcomes (6)

• The area under the curve representing the change in mean arterial pressure during the induction period relative to the baseline.

  from start of induction to 15 minutes after induction

• The dosage of vasoactive drugs

  from start of induction to 15 minutes after induction

• lowest MAP

  from start of induction to 15 minutes after induction

• standard deviation of R-R intervals (SDRR)

  from start of induction to 15 minutes after induction

• ratio of low-frequency HRV/high-frequency HRV (LF/HF ratio)

  from start of induction to 15 minutes after induction

Study Arms (3)

High-frequency

EXPERIMENTAL

The electrical stimulation is provided at a frequency of 100Hz

Other: electrical acupoint stimulation; Other: electrodes pasted; Other: high-frequency electrical stimulation

Low-frequency

EXPERIMENTAL

The electrical stimulation is provided at a frequency of 2Hz

Other: electrical acupoint stimulation; Other: electrodes pasted; Other: low-frequency electrical stimulation

No stimulation

SHAM COMPARATOR

Only electrodes are pasted

Other: electrodes pasted

Interventions

electrical acupoint stimulation OTHER

electrical acupoint stimulation are administered at Neiguan and Jian Shi. The stimulation starts at 15 minutes before anesthesia induction and ends at 15 minutes after anesthesia induction.

High-frequency; Low-frequency

electrodes pasted OTHER

Electrodes are pasted at Neiguan and Jianshi

High-frequency; Low-frequency; No stimulation

high-frequency electrical stimulation OTHER

The frequency of electrical stimulation is 100Hz

High-frequency

low-frequency electrical stimulation OTHER

The frequency of electrical stimulation is 2Hz

Low-frequency

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• aged over 65 yrs old
• elective abdominal surgery under general anesthesia
• written infromed consent

You may not qualify if:

• American society of anesthesiologists status over 3
• New York Heart Association (NYHA) Functional Classification≥Ⅲ
• severe arrhythmia leading to hemodynamic instability
• uncontrolled diabetes
• hypertension patients stratified as very high risk according to cardiovascular risk classification
• people who have TEAS contraindications such as local acupoint skin injury or infection and implanted cardiac pacemaker

Sponsors & Collaborators

• Zhihong LU: lead

Related Publications (2)

• Kaduk K, Petrella A, Muller SJ, Koenig J, Kroemer NB. Non-Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load. Psychophysiology. 2025 Feb;62(2):e70017. doi: 10.1111/psyp.70017.

  PMID: 40007175 BACKGROUND

• Chaitman BR, Bitar SR. Is ST segment elevation non-Q-wave myocardial infarction after thrombolytic therapy a new clinical entity that requires an invasive management strategy? J Am Coll Cardiol. 2001 Jan;37(1):26-9. doi: 10.1016/s0735-1097(00)01053-6. No abstract available.

  PMID: 11153749 BACKGROUND

Central Study Contacts

Zhihong Lu

CONTACT

86-13891975018; deerlu23@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: February 25, 2026
• Study Start: September 15, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: September 15, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: after publication
• Access Criteria: with request to Dr. Zhihong Lu