Echocardiography-derived Pre-induction Hemodynamic Phenotypes and Post-induction Hypotension: an Exploratory Clustering Analysis

NCT07509255 | Completed

• 1 other identifier: PIH-Hemo-Phenotypes
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes. Using previously collected clinical and echocardiographic data, the study explored the relationship between pre-induction hemodynamic status and the risk of developing PIH. The findings may help improve preoperative risk stratification and support more individualized perioperative hemodynamic management.

Conditions

Post-induction Hypotension (PIH)

Keywords

General anaesthesia; Transthoracic echocardiography; Post-induction hypotension; Hemodynamic phenotypes

Outcome Measures

Primary Outcomes (2)

• Pre-induction hemodynamic phenotype classification

  Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.

  pre-induction, before administration of general anesthesia: from admission to the operating to induction of general anesthesia

• Pre-induction hemodynamic phenotype classification

  Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.

  Baseline (pre-induction, before administration of general anesthesia)

Study Arms (1)

Overall Study Cohort

Adult patients undergoing elective surgery under general anesthesia included in a retrospective analysis of prospectively collected data.

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged over 50 years scheduled for elective abdominal surgery under general anesthesia.

You may qualify if:

• Patients scheduled for elective abdominal surgery under genral anesthesia.

You may not qualify if:

• patients with dyspnoea
• unstable angina,
• severe valvular heart disease
• anticipated or unanticipated difficult airway management
• suspected increased intra-abdominal pressure
• poor echogenicity.

Sponsors & Collaborators

• Avicenna Military Hospital: lead

Study Sites (1)

Cadi Ayyad University . Avicenna Military Hospital

Marrakesh, Marrakech, 10000, Morocco

Location

Related Publications (1)

• Aissaoui Y, Jozwiak M, Bahi M, Belhadj A, Alaoui H, Qamous Y, Serghini I, Seddiki R. Prediction of post-induction hypotension by point-of-care echocardiography: A prospective observational study. Anaesth Crit Care Pain Med. 2022 Aug;41(4):101090. doi: 10.1016/j.accpm.2022.101090. Epub 2022 May 1.

  PMID: 35508291 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of critical care and anesthesiology

Study Record Dates

• First Submitted: March 28, 2026
• First Posted: April 3, 2026
• Study Start: February 1, 2020
• Primary Completion: March 30, 2020
• Study Completion: March 30, 2020
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: April 30th, 2026
• Access Criteria: Qualified healthcare providers or researchers De-identified individual participant data (including clinical and echocardiographic variables underlying the reported results)

Locations

MO (1)